Biology of the Perimenopause: Impact on Health and Aging in Non-Reproductive Somatic and Neuronal Tissues

The summary for the Biology of the Perimenopause: Impact on Health and Aging in Non-Reproductive Somatic and Neuronal Tissues grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.

Biology of the Perimenopause: Impact on Health and Aging in Non-Reproductive Somatic and Neuronal Tissues: -The goal of this RFA is solicit applications for research studies to better understand underlying biologic mechanisms associated with the increased risk for, or decreased protection leading to, health problems and conditions associated with the menopausal process in middle-aged women. The focus is on a) how hypothalamic-pituitary-ovarian (H-P-O) axis hormone levels and dynamic changes in hormone levels across the menopausal transition affect pathophysiologic processes within non-reproductive somatic and neuronal target tissues, b) the role of steroid hormone biosynthesis and/or metabolism within non-reproductive somatic and neuronal tissues on pathophysiologic processes within these tissues across the menopausal transition, and c) the role of aging on these pathophysiologic processes. General research areas that may be addressed in applications responsive to this RFA include: a) model systems, including appropriate clinical and animal model systems; b! ) biologic impact of altered H-P-O axis hormones and hormonal dynamics across the menopausal transition on pathophysiologic processes in non-reproductive somatic or neuronal tissues; and c) biologic impact and regulation of steroid hormone synthesis/metabolism in non-reproductive somatic or neuronal tissues during and following the menopause transition. - This RFA is limited to studies addressing the underlying BIOLOGY of endogenous H-P-O axis hormones and their interactions with non-reproductive organ systems. Studies involving clinical trials or therapeutic interventions will NOT be responsive. - The total amount to be awarded: $2.5M - The anticipated number of awards: 4-6 - The types of mechanisms: R21 and R01 - Eligible organizations include: for-profit and non-profit, domestic and foreign public or private institutions, units of State and local governments, and eligible agencies of the Federal government - Eligible principal investigators include any individuals with the skills, knowledge, and resources necessary to carry out the proposed research. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are encouraged to apply - Applicants may submit as many scientifically different applications as desired.