Characterization of Circulating Pro- and Anti-Geronic Proteins and Peptides (R01)
The summary for the Characterization of Circulating Pro- and Anti-Geronic Proteins and Peptides (R01) grant is detailed below.
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Characterization of Circulating Pro- and Anti-Geronic Proteins and Peptides (R01): The goal of this FOA is to advance research on the underlying basis for the transfer (or transposition) of aging phenotypes observed between young and old rodents and discovered through heterochronic parabiosis. Examples of transposed phenotypes include reversal of cardiac hypertrophy, partial restoration of cognitive function, improved vascularization, and repair of skeletal muscle after cryo-injury (anti-geronic transposition), or as accelerated loss of cognitive function and neurogenesis (pro-geronic transposition). Other transposed phenotypes, as revealed solely through heterochronic parabiosis, may also be reported in the literature. There are also reports of candidate factors found in circulation that might be causally related to the transposition of these aging phenotypes; these are termed "circulating geronic factors" for purposes of this FOA. To date, these are proteins and peptides that pass between the young and old mice joined by parabiosis, due to anastomosis of their circulatory systems. Based on these novel findings and this novel experimental paradigm, the specific objective of this FOA is to test whether these candidate geronic factors are necessary for the transposition of aging phenotypes. The focus is on phenotypes transposed in heterochronic parabiosis and the candidate factors which are present and functional at physiological concentrations in circulation.
| Federal Grant Title: | Characterization of Circulating Pro- and Anti-Geronic Proteins and Peptides (R01) |
| Federal Agency Name: | National Institutes of Health |
| Grant Categories: | Health |
| Type of Opportunity: | Discretionary |
| Funding Opportunity Number: | RFA-AG-17-002 |
| Type of Funding: | Grant |
| CFDA Numbers: | 319197 |
| CFDA Descriptions: | Aging Research |
| Current Application Deadline: | Feb 2, 2017 |
| Original Application Deadline: | Feb 2, 2017 |
| Posted Date: | Feb 24, 2016 |
| Creation Date: | Feb 24, 2016 |
| Archive Date: | Mar 5, 2017 |
| Total Program Funding: | $2,350,000 |
| Maximum Federal Grant Award: | $350,000 |
| Minimum Federal Grant Award: | none |
| Expected Number of Awards: | 6 |
| Cost Sharing or Matching: | No |
- Applicants Eligible for this Grant
- Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
County governments
Native American tribal governments (Federally recognized)
Public and State controlled institutions of higher education
City or township governments
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Small businesses
Public housing authorities/Indian housing authorities
Special district governments
Independent school districts
State governments
Private institutions of higher education
For profit organizations other than small businesses - Additional Information on Eligibility
- Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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