Deep Sequencing and Haplotype Profiling of Mental Disorders

The summary for the Deep Sequencing and Haplotype Profiling of Mental Disorders grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.

Deep Sequencing and Haplotype Profiling of Mental Disorders: With the initial stages of the Human Genome Project completed and new insights gained into the complex interplay of genomic function, genomic structure and the environment in mental disorders, attention is shifting towards the translational promise of the completed human sequence and a new era of genomic medicine in mental disorders. However, there are still major obstacles that need to be addressed before this occurs. It will be necessary to see a confluence of developments in genomic technologies and epidemiological methods, such as high throughput sequencing of candidate genes or genomic regions; global single nucleotide polymorphism (SNP) or haplotype analysis; improved measurements of environmental factors; well-characterized clinical phenotypes and endophenotypes; and the development of new analytical approaches. Furthermore, these advances will have to be applied in carefully crafted study designs and, implicitly, in large samples. A special emp! hasis of this initiative is to support applications that implement large-scale studies and innovative analytical designs that will disaggregate a given mental disorder into components of finite risks. These developments may be evolutionary or may be fundamentally new and may lead to paradigm shifts in the field. Applications written in response to this PA may propose new technologies for cost effective whole genome analysis and in-depth sequencing and analysis of candidate genes and genomic regions in pedigrees or in a sample of unrelated cases with mental disorders. Proposals for large-scale haplotype analysis and the development of new analytical methods also are encouraged. Projects funded under this program will focus on phenotypically well-characterized samples from the NIMH Human Genetics Initiative (http://nimhgenetics.org/) but may also use existing sample collections not included in the repository and study one of seven mental disorders: anorexia nervosa, attention! deficit hyperactivity disorder, autism and related autism spectrum disorders, depression, bipolar disorder, obsessive compulsive disorder and schizophrenia. To take into account the rapid technological and scientific developments now occurring in genetics, proposals funded under this initiative will be restricted to a three-year period. Results from research funded under this initiative will have direct implications for diagnosis, treatment and ultimately prevention of mental disorders.