Development and Improvement of Inbred ES Cell Lines for Use in Generation of Mouse Mutants

The summary for the Development and Improvement of Inbred ES Cell Lines for Use in Generation of Mouse Mutants Federal Grant is detailed below. It contains information such as the Catalog of Federal Domestic Assistance (CFDA) number, who is eligible for the grant, how much grant money will be awarded, important deadlines, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed in the Grant Announcement Contact section. If these sections are incomplete, please visit the website of the government agency that is offering this grant.


	Federal Grant Title:	Development and Improvement of Inbred ES Cell Lines for Use in Generation of Mouse Mutants
	CFDA Number:	93.12193.172
	CFDA Description:	Oral Diseases and Disorders Research 93.172 Human Genome Research
	Federal Agency Name:	National Institutes of Health
	Category of Funding Activity:	Education Food and Nutrition Health Income Security and Social Services
	Category Explanation:	Information not provided
	Opportunity Category:	Discretionary
	Funding Opportunity Number:	RFA-DA-06-009
	Document Type:	Grants Notice
	Funding Instrument Type:	Cooperative Agreement
	Posted Date:	Sep 16, 2005
	Creation Date:	Sep 16, 2005
	Original Closing Date for Applications:	Nov 22, 2005
	Current Closing Date for Applications:	Information not provided
	Archive Date:	Dec 22, 2005
	Expected Number of Awards:	Information not provided
	Estimated Total Program Funding:	$4,800,000
	Federal Grant Award Ceiling:	$1,000,000
	Federal Grant Award Floor:	Information not provided
	Cost Sharing or Matching Requirement:	93.173 -- Research Related to Deafness and Communication Disorders

Applicants Eligible for this Grant: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Small businesses Public and State controlled institutions of higher education Private institutions of higher education State governments County governments City or township governments Special district governments Independent school districts Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled "Additional Information on Eligibility" for clarification)
Additional Information on Eligibility: Eligible agencies of the Federal Government are eligible to apply. Foreign institutions are eligible to apply.
Grant Description: - The goal of this RFA is to improve the efficiency of germline transmission of C57BL/6 ES lines to an extent that permits the use of C57BL/6 ES cell for high throughput gene targeting and the efficient production of C57BL/6 mice carrying a null mutation. - Up to $1.6 million per year for three years is to be awarded through this RFA. - It is anticipated that 1 to 3 awards will be made. - It is anticipated the awards will be funded in July, 2006 for three years. - Awards will be made using the Cooperative Agreement (U01) mechanism. - Eligible organizations include for-profit or non-profit organizations; public or private institutions, such as universities, colleges, hospitals, and laboratories; units of State and local governments; eligible agencies of the Federal government, domestic or foreign; NIH Intramural laboratories may participate as collaborators. Applicants for this RFA must have a proven track record of producing or developing existing ES lines, preferably from C57BL/6 mice, and have themselves or their collaborators used such lines to create mutant germline competent ES cells by targeted, gene trap or transposon mutagenesis. Experience must support the proposed goals to develop a robust ES cell line(s). Documentation of this track record must be included. - Eligible principal investigators with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with his/her institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. - Applicants may submit more than one application, provided they are scientifically distinct. - Investigators who applied for the RFA, "Completion of a Comprehensive Mouse Knockout Resource" (RFA-HG-05-007.) are encouraged to apply. - See Section IV.1 for application materials. - Telecommunications for the hearing impaired is available at: TTY 301-451-0088.
Link to Full Grant Announcement: http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-06-009.html http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-06-009.html
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