Diet, Epigenetic Events, and Cancer Prevention (R01)

The summary for the Diet, Epigenetic Events, and Cancer Prevention (R01) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.

Diet, Epigenetic Events, and Cancer Prevention (R01): -The aim of this funding opportunity announcement (FOA) is to promote clinical and preclinical research to determine how diet and dietary factors, including dietary supplements, impact DNA methylation, histone posttranslational modification, and other epigenetic processes involved in cancer prevention and development. Another important aim of this FOA is to encourage collaborations between nutrition and epigenetic experts to study bioactive food components with cancer-preventative properties and to examine key epigenetic events in cancer processes (e.g., carcinogen metabolism, cell division, differentiation, and apoptosis) in order to begin to establish linkages between epigenetics, methylation patterns, and tumor incidences/behaviors. NIAAA is specifically interested in receiving applications that examine the impact(s) of chronic alcohol consumption on levels of SAM, betaine, and folate, and possible associations with DNA methylation and cancer. NIDDK is particularly interested in receiving applications that address normal and neoplastic conditions focusing on the impact of epigenetics on cell division, differentiation and/or apoptosis in the GI tract and related organs. -This FOA will use the NIH research project grant (R01) award mechanism and runs in parallel with two other FOAs of identical scientific scope, one being PA-06-414, which solicits applications using the NIH Small Grant (R03) award mechanism, and the other being PA-06-413 which solicits applications using the NIH exploratory/developmental (R21) grant mechanism. -Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. -The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. -You may submit an application(s) if your institution has any of the following characteristics: for-profit organizations; non-profit organizations; public or private institutions, such as universities, colleges, hospitals, and laboratories; units of State governments; units of local governments; eligible agencies of the Federal government; Foreign institutions; Domestic institutions; and faith-based or community-based organizations; Indian/Native American Tribal Governments (Federally Recognized); Indian/Native American Tribal Governments (Other than Federally Recognized); and Indian/Native American Tribally Designated Organizations. Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. -Applicants may each submit more than one application, provided that they are scientifically distinct.