DoD Amyotrophic Lateral Sclerosis, Therapeutic Idea Award

The summary for the DoD Amyotrophic Lateral Sclerosis, Therapeutic Idea Award grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the Dept of the Army USAMRAA, which is the U.S. government agency offering this grant.
DoD Amyotrophic Lateral Sclerosis, Therapeutic Idea Award: The Therapeutic Idea Award is designed to promote new ideas aimed at drug or treatment discovery that are still in the early stages of development. Projects that focus primarily on investigating the pathophysiology of ALS are not within the scope of this Program Announcement/Funding Opportunity. Development and/or modification of preclinical model systems or the application of high-throughput screens to define or assess lead compounds for ALS treatment are of interest. Development of methods to adequately measure target binding and proximal downstream effects (target engagement) and the potential for undesirable activities at related but unintended targets (selectivity) are also encouraged. While the inclusion of preliminary data is not prohibited, the strength of the application should not rely on preliminary data, but on the innovative approach. All proposed research projects should include a well- formulated, testable hypothesis based on strong scientific rationale that holds translational potential to improve ALS treatment and/or advance a novel treatment modality. Innovation and impact are important aspects of the Therapeutic Idea Award. Research deemed innovative may introduce a new paradigm, challenge current paradigms, introduce novel concepts or technologies, or exhibit other uniquely creative qualities that may lead to potential therapeutics for ALS. Impact may be near-term or long-term, but must be significant and move beyond an incremental advancement. Identification of treatment approaches using biological correlates of disease activity and progression in pre-existing human specimens from well-characterized, adequately controlled, and sufficiently powered patient cohorts is encouraged. Examples of acceptable cohorts for study include controlled clinical trials, observational studies, and registries (e.g., Centers for Disease Control and Prevention National ALS Registry and/or Biorepository; https://www.cdc.gov/als/Default.html). Active duty military and/or Veteran patient populations or resources should be considered. All specimens must exist at the time of application submission; collection of new specimens will not be supported. The Therapeutic Idea Award encourages applications that include meaningful and productive collaborations between investigators. As appropriate, applicants are encouraged to collaborate with established ALS researchers. Applicants seeking support for the development of products beyond drug or treatment discovery should consider the FY18 ALSRP Therapeutic Development Award (Funding Opportunity Number: W81XWH-18-ALSRP-TDA), which supports advanced preclinical development activities (http://cdmrp.army.mil/funding/alsrp). The proposed research must be relevant to active duty Service Members, Veterans, military beneficiaries, and/or the American public.
Federal Grant Title: DoD Amyotrophic Lateral Sclerosis, Therapeutic Idea Award
Federal Agency Name: Dept of the Army USAMRAA (DOD-AMRAA)
Grant Categories: Science and Technology
Type of Opportunity: Discretionary
Funding Opportunity Number: W81XWH-18-ALSRP-TIA
Type of Funding: Cooperative Agreement
CFDA Numbers: 12.420
CFDA Descriptions: Information not provided
Current Application Deadline: October 11th, 2018
Original Application Deadline: October 11th, 2018
Posted Date: April 10th, 2018
Creation Date: April 10th, 2018
Archive Date: November 10th, 2018
Total Program Funding: $4,000,000
Maximum Federal Grant Award:
Minimum Federal Grant Award:
Expected Number of Awards: 5
Cost Sharing or Matching: No
Last Updated: April 10th, 2018
Applicants Eligible for this Grant
Unrestricted (i.e., open to any type of entity below), subject to any clarification in text field entitled "Additional Information on Eligibility"
Grant Announcement Contact
CDMRP Help Desk
Phone: 301-682-5507
Email: [email protected]
CDMRP Help Desk
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