DoD Breast Cancer Breakthrough Award Levels 3 and 4

The summary for the DoD Breast Cancer Breakthrough Award Levels 3 and 4 grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the Other Agency, which is the U.S. government agency offering this grant.
DoD Breast Cancer Breakthrough Award Levels 3 and 4: The intent of the Breakthrough Award is to support promising research that has high potential to lead to or make breakthroughs in breast cancer. The critical components of this award mechanism are:

Impact: Research supported by the Breakthrough Award will have the potential for a major impact and accelerate progress toward ending breast cancer. The impact may be near-term or long-term, but must be significant and move beyond an incremental advancement. Applications must articulate the pathway to making a clinical impact for individuals with, or at risk for, breast cancer, even if clinical impact is not an immediate outcome.

Research Scope: Research proposed under this award mechanism may be small- to large-scale projects, at different stages of idea and research development. Two additional funding levels, Funding Levels 1 and 2, are available under a different Program Announcement/Funding Opportunity (W81XWH-16-BCRP-BREAKTHROUGH2_FL12). It is the responsibility of the Principal Investigator (PI) to select the funding level that is most appropriate for the research proposed. The funding level should be selected based on the scope of the research project, rather than the amount of the budget.

The following are general descriptions, although not all-inclusive, of the scope of research projects that would be appropriate to propose under each funding level:

• Funding Level 3: Advanced translational studies that have potential for near-term clinical investigation. Small-scale clinical trials may apply.

• Funding Level 4: Large-scale projects that will transform and revolutionize the clinical management and/or prevention of breast cancer. Near-term clinical impact is expected. PIs are expected to have experience in successfully leading large-scale projects.

Note: An invited oral presentation is a requirement for application review of Funding Level 4 projects, as described in Section II.C., Full Application Submission Content.

Partnering PI Option: The Breakthrough Award encourages applications that include meaningful and productive collaborations between investigators. The Partnering PI Option is structured to accommodate two PIs, referred to as the Initiating PI and the Partnering PI, each of whom will receive a separate award. The Initiating and Partnering PIs have different submission requirements; however, both PIs should contribute significantly to the development of the proposed research project including the Project Narrative, Statement of Work, and other required components. The PIs may have expertise in similar or disparate scientific disciplines, but each PI is expected to bring distinct contributions to the application. New collaborations are encouraged, but not required. It is the responsibility of the PIs to describe how their combined expertise will better address the research question and explain why the work should be done together rather than through separate efforts. To meet the intent of the Partnering PI Option, applicants are discouraged from submitting as a Partnering PI on multiple applications unless they are clearly addressing distinct research questions. Applications submitted by a mentor and his/her current postdoctoral fellow or junior investigator as Initiating and Partnering PIs do not meet the intent of the Partnering PI Option.

Personnel: PIs are expected to engage and assemble an appropriate and robust research team with the combined backgrounds and breast cancer-related expertise to enable successful conduct of the project.

Consumer Advocates: Applications are required to include consumer advocate involvement. The research team must include two or more breast cancer consumer advocates who will be integral throughout the planning and implementation of the research project. Consumer advocates should be involved in the development of the research question, project design, oversight, recruitment, and evaluation, as well as other significant aspects of the proposed project. Interactions with other team members should be well integrated and ongoing, not limited to attending seminars and semi-annual meetings. As lay representatives, the consumer advocates must be individuals who have been diagnosed with breast cancer, and they should be active in a breast cancer advocacy organization. Their role in the project should be independent of their employment, and they cannot be employees of any of the organizations participating in the application. Their role should be focused on providing objective input on the research and its potential impact for individuals with, or at risk for, breast cancer. The consumer advocates should have a high level of knowledge of current breast cancer issues and the necessary background or training in breast cancer research to contribute to the project.
Federal Grant Title: DoD Breast Cancer Breakthrough Award Levels 3 and 4
Federal Agency Name: Other Agency
Grant Categories: Other
Type of Opportunity: Discretionary
Funding Opportunity Number: W81XWH-16-BCRP-BREAKTHROUGH2-FL34
Type of Funding: Information not provided
CFDA Numbers: 327943
CFDA Descriptions: Military Medical Research and Development
Current Application Deadline: Dec 8, 2016
Original Application Deadline: Dec 8, 2016
Posted Date: Jul 19, 2016
Creation Date: Jul 19, 2016
Archive Date: Jan 7, 2017
Total Program Funding: $24,800,000
Maximum Federal Grant Award: none
Minimum Federal Grant Award: none
Expected Number of Awards: 3
Cost Sharing or Matching: No
Applicants Eligible for this Grant
Information not provided
Grant Announcement Contact
CDMRP Help Desk Email: [email protected] Phone: 301-682-5507
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