Identification of Biomarkers for Early Detection of Environmentally-Induced Mitochondrial Dysfunction (R01)

The summary for the Identification of Biomarkers for Early Detection of Environmentally-Induced Mitochondrial Dysfunction (R01) Federal Grant is detailed below. It contains information such as the Catalog of Federal Domestic Assistance (CFDA) number, who is eligible for the grant, how much grant money will be awarded, important deadlines, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed in the Grant Announcement Contact section. If these sections are incomplete, please visit the website of the government agency that is offering this grant.


	Federal Grant Title:	Identification of Biomarkers for Early Detection of Environmentally-Induced Mitochondrial Dysfunction (R01)
	CFDA Number:	93.113
	CFDA Description:	Environmental Health
	Federal Agency Name:	National Institutes of Health
	Category of Funding Activity:	Environment Health
	Category Explanation:	Information not provided
	Opportunity Category:	Discretionary
	Funding Opportunity Number:	RFA-ES-11-007
	Document Type:	Grants Notice
	Funding Instrument Type:	Grant
	Posted Date:	Nov 30, 2010
	Creation Date:	Nov 30, 2010
	Original Closing Date for Applications:	Feb 03, 2011
	Current Closing Date for Applications:	Feb 03, 2011
	Archive Date:	Mar 06, 2011
	Expected Number of Awards:	Information not provided
	Estimated Total Program Funding:	$2,500,000
	Federal Grant Award Ceiling:	Information not provided
	Federal Grant Award Floor:	Information not provided
	Cost Sharing or Matching Requirement:	No

Applicants Eligible for this Grant: State governments - County governments - City or township governments - Special district governments - Independent school districts - Public and State controlled institutions of higher education - Native American tribal governments (Federally recognized) - Public housing authorities/Indian housing authorities - Native American tribal organizations (other than Federally recognized tribal governments) - Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education - Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education - Private institutions of higher education - For profit organizations other than small businesses - Small businesses - Others (see text field entitled "Additional Information on Eligibility" for clarification)
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Grant Description: This funding opportunity announcement (FOA) encourages grant applications from institutions/organizations to develop biomarkers of mitochondrial dysfunction using animal models and other experimental models that can help to identify environmental stressors that inhibit normal mitochondrial function, improve our mechanistic understanding of the effects of mitochondrial toxicants, and develop approaches and candidate markers that will serve as the basis for developing biomarkers of early mitochondrial dysfunction in human population studies linking exposure to disease. Mitochondrial biology is complex, with different responses to stressors, diet composition, and genetic factors observed in different tissues and at different stages of development. Before early biomarkers of mitochondrial dysfunction can be fully developed for human studies, a number of important issues need to be addressed, including enhancing the understanding of how the more severe effects on mitochondrial function in target tissues relate to milder effects in surrogate tissues, understanding whether alterations in mitochondrial endpoints are adaptive or adverse (transient or persistent) effects, and determining which endpoints signal early effects on mitochondrial function before more severe tissue phenotypes are apparent. Many of these questions can be addressed through development of relevant animal and other experimental models to identify robust markers of mitochondrial dysfunction associated with genetic and environmental factors.
Link to Full Grant Announcement: http://grants.nih.gov/grants/guide/rfa-files/rfa-es-11-007.html
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