In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk (R01)

The summary for the In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk (R01) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.

In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk (R01): -Purpose. This Funding Opportunity Announcement (FOA) solicits innovative preclinical applications that propose research that will enhance the understanding of the relationship between exposures to bioactive food components and/or environmental chemicals in utero, hormonal and growth-factor response, gene expression or epigenetic changes, and subsequent mammary cancer risk in preclinical models. Although much evidence suggests that dietary components are linked to cancer prevention, the specific nutrients, sites of action, and role of exposure in utero remain elusive. Similarly, there are data suggesting a role for environmental agents such as mycotoxins, heterocyclic amines, and environmental chemicals with endocrine activity in the etiology of mammary cancer but the doses, windows of susceptibility, and mechanisms are unclear. This FOA encourages applications that apply new high-throughput genomic, epigenomic, proteomic, and metabolomic technologies to determine how dietary exposures in utero influence adult breast cancer susceptibility. The resulting information will help define effective maternal dietary intervention strategies for breast cancer prevention in her offspring. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism and runs in parallel with an FOA of identical scientific scope, PA-06-277, that solicits applications under the Exploratory/Developmental Grant (R21) award mechanism. -Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.