Integrative Omics to Enhance Therapeutics Development for Healthy Aging (UH2/UH3 Clinical Trial Not Allowed)
The summary for the Integrative Omics to Enhance Therapeutics Development for Healthy Aging (UH2/UH3 Clinical Trial Not Allowed) grant is detailed below.
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Integrative Omics to Enhance Therapeutics Development for Healthy Aging (UH2/UH3 Clinical Trial Not Allowed): This Funding Opportunity Announcement (FOA) is a phased innovation initiative to facilitate multi-omics/integrative approaches to identify omics profiles associated with protection against multiple aging conditions, with exceptional health span, and to refine strategies for utilizing these profiles for therapeutics development. Specifically, a phased innovation cooperative agreement mechanism (UH2/UH3) involving an interdisciplinary research team will be used to support a single project that will conduct integrative analysis of person -specific multiple omics measurements (e.g., transcriptomics, proteomics, metabolomics) generated across multiple tissues ; the multi-omic profiling should be conducted on individuals from extensively phenotyped cohorts with substantial numbers of long-lived individuals with characteristics of exceptionally healthy aging and appropriate controls. It will also: 1) harmonize and extend the use of existing phenotypic data from these studies to apply phenomics to transcriptomic, proteomic, metabolomic findings, 2) select animal model species or strains with varying life spans for comparative omics studies and identify potential determinants of species differences in longevity and rates of disease development, 3) develop appropriate computational and analytical tools to identify omics profiles associated with exceptional longevity and healthy aging, 4) apply translational bioinformatics approaches and leverage existing publicly available drug signatures databases to identify molecules that could produce profiles associated with exceptionally healthy aging and 5) exchange data with other NIH/NIA-supported related omics activities and other public-private partnerships (e.g., Trans-Omics for Precision Medicine (TOPMed), Accelerating Medicines Partnership- Alzheimers Disease (AMP-AD) for data harmonization and analysis.
Federal Grant Title: | Integrative Omics to Enhance Therapeutics Development for Healthy Aging (UH2/UH3 Clinical Trial Not Allowed) |
Federal Agency Name: | National Institutes of Health (HHS-NIH11) |
Grant Categories: | Health |
Type of Opportunity: | Discretionary |
Funding Opportunity Number: | RFA-AG-19-011 |
Type of Funding: | Cooperative Agreement |
CFDA Numbers: | 93.866 |
CFDA Descriptions: | Information not provided |
Current Application Deadline: | November 14th, 2018 |
Original Application Deadline: | November 14th, 2018 |
Posted Date: | June 27th, 2018 |
Creation Date: | June 27th, 2018 |
Archive Date: | December 20th, 2018 |
Total Program Funding: | $5,000,000 |
Maximum Federal Grant Award: | $3,300,000 |
Minimum Federal Grant Award: | |
Expected Number of Awards: | 1 |
Cost Sharing or Matching: | No |
Last Updated: | June 27th, 2018 |
- Applicants Eligible for this Grant
- State governments - County governments - City or township governments - Special district governments - Independent school districts - Public and State controlled institutions of higher education - Native American tribal governments (Federally recognized) - Public housing authorities/Indian housing authorities - Native American tribal organizations (other than Federally recognized tribal governments) - Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education - Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education - Private institutions of higher education - For-profit organizations other than small businesses - Small businesses - Others (see text field entitled "Additional Information on Eligibility" for clarification.)
- Additional Information on Eligibility
- Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
- Link to Full Grant Announcement
- http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-19-011.html
- Grant Announcement Contact
- NIH OER Webmaster
[email protected]
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