International Studies of Aids-Associated Co-Infections (Isaac)

The summary for the International Studies of Aids-Associated Co-Infections (Isaac) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.

International Studies of Aids-Associated Co-Infections (Isaac): The National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), invites applications for cooperative agreement (U01) grants from US based investigators to conduct International Studies of AIDS-associated Co-infections (ISAAC). The ISAAC grant will support clinical studies of co-infections with HIV and one or more pathogens (including but not limited to tuberculosis, other AIDS-defining opportunistic infections, malaria and other parasitic infections) endemic among adults and children in resource- constrained tropical countries (countries that have territories within the geographically defined tropical zones, i.e. the countries with territories between the tropic of Cancer and the tropic of Capricorn characterized by hot climate) . The initial goal of this program is to conduct clinical research to determine the spectrum, incidence, clinical manifestations, and outcomes of these co-infections in a specific region, and evaluate the pathogenic interactions between HIV and endemic infections. Applications for projects addressing therapeutic goals will be acceptable if the epidemiology of the co- infections is already adequately defined in the region. Long-term goals are to develop effective and sustainable clinical management strategies to improve local standards of care and to foster the integration of research for HIV and the relevant co-pathogens. In reviewing applications, a major emphasis will be placed on training, technology development, and enhancing independent research capacities in host country sites. Collaborative teams inclusive of research expertise in HIV and in tropical pathogens are required. Projects must be designed to increase relevant research experience of host country investigators and to enhance their ability to pursue scientific opportunities by training, study planning and performance, and improving technical ability.