Investigation of Peptide-Polymer Interaction in Poly(lactide-co-glycolide) Microspheres (U01)
The summary for the Investigation of Peptide-Polymer Interaction in Poly(lactide-co-glycolide) Microspheres (U01) grant is detailed below.
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Investigation of Peptide-Polymer Interaction in Poly(lactide-co-glycolide) Microspheres (U01): Although biodegradable poly(lactide-co-glycolide) (PLGA) polymers have been utilized extensively for the controlled release of peptide drugs, there is still a lack of in-depth understanding of peptide-polymer interaction in PLGA based microspheres. The purpose of the present study is to develop a systematic approach to assess the peptide-polymer interaction in PLGA based microsphere dosage forms. The developed approach should be able to identify the different types of peptide-polymer interactions, characterize and quantify related peptide degradation impurities (e.g., acylation peptide adducts), and determine the formulation parameters, hydration and degradation factors, and manufacturing processes responsible for facilitating peptide-polymer interaction. The results from this study will provide better understanding of peptide-polymer interaction in PLGA based drug delivery systems, which will help the Agency in developing recommendations for evaluation of generic microspheres containing peptide drugs.
| Federal Grant Title: | Investigation of Peptide-Polymer Interaction in Poly(lactide-co-glycolide) Microspheres (U01) |
| Federal Agency Name: | Food and Drug Administration |
| Grant Categories: | Consumer Protection Food and Nutrition Health |
| Type of Opportunity: | Discretionary |
| Funding Opportunity Number: | RFA-FD-16-012 |
| Type of Funding: | Cooperative Agreement |
| CFDA Numbers: | 319898 |
| CFDA Descriptions: | Food and Drug Administration_Research |
| Current Application Deadline: | May 20, 2016 |
| Original Application Deadline: | May 20, 2016 |
| Posted Date: | Mar 17, 2016 |
| Creation Date: | Mar 17, 2016 |
| Archive Date: | Jun 19, 2016 |
| Total Program Funding: | $250,000 |
| Maximum Federal Grant Award: | $250,000 |
| Minimum Federal Grant Award: | none |
| Expected Number of Awards: | 1 |
| Cost Sharing or Matching: | No |
- Applicants Eligible for this Grant
- For profit organizations other than small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
County governments
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
Independent school districts
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Special district governments
City or township governments
Private institutions of higher education
Public housing authorities/Indian housing authorities
Small businesses
State governments - Additional Information on Eligibility
- Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organization are not eligible to apply.
Foreign components, are not allowed. - Link to Full Grant Announcement
- Full Announcement of RFA-FD-16-012
- Grant Announcement Contact
- Eric Bozoian
Grants Management Specialist
Phone 2404027623
point of contact
Food and Drug Administration 240-402-7592