Investigation of Peptide-Polymer Interaction in Poly(lactide-co-glycolide) Microspheres (U01)

The summary for the Investigation of Peptide-Polymer Interaction in Poly(lactide-co-glycolide) Microspheres (U01) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the Food and Drug Administration, which is the U.S. government agency offering this grant.
Investigation of Peptide-Polymer Interaction in Poly(lactide-co-glycolide) Microspheres (U01): Although biodegradable poly(lactide-co-glycolide) (PLGA) polymers have been utilized extensively for the controlled release of peptide drugs, there is still a lack of in-depth understanding of peptide-polymer interaction in PLGA based microspheres. The purpose of the present study is to develop a systematic approach to assess the peptide-polymer interaction in PLGA based microsphere dosage forms. The developed approach should be able to identify the different types of peptide-polymer interactions, characterize and quantify related peptide degradation impurities (e.g., acylation peptide adducts), and determine the formulation parameters, hydration and degradation factors, and manufacturing processes responsible for facilitating peptide-polymer interaction. The results from this study will provide better understanding of peptide-polymer interaction in PLGA based drug delivery systems, which will help the Agency in developing recommendations for evaluation of generic microspheres containing peptide drugs.
Federal Grant Title: Investigation of Peptide-Polymer Interaction in Poly(lactide-co-glycolide) Microspheres (U01)
Federal Agency Name: Food and Drug Administration
Grant Categories: Consumer Protection Food and Nutrition Health
Type of Opportunity: Discretionary
Funding Opportunity Number: RFA-FD-16-012
Type of Funding: Cooperative Agreement
CFDA Numbers: 319898
CFDA Descriptions: Food and Drug Administration_Research
Current Application Deadline: May 20, 2016
Original Application Deadline: May 20, 2016
Posted Date: Mar 17, 2016
Creation Date: Mar 17, 2016
Archive Date: Jun 19, 2016
Total Program Funding: $250,000
Maximum Federal Grant Award: $250,000
Minimum Federal Grant Award: none
Expected Number of Awards: 1
Cost Sharing or Matching: No
Applicants Eligible for this Grant
For profit organizations other than small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
County governments
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
Independent school districts
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Special district governments
City or township governments
Private institutions of higher education
Public housing authorities/Indian housing authorities
Small businesses
State governments
Additional Information on Eligibility
Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organization are not eligible to apply.
Foreign components, are not allowed.
Link to Full Grant Announcement
Full Announcement of RFA-FD-16-012
Grant Announcement Contact
Eric Bozoian Grants Management Specialist Phone 2404027623
point of contact

Food and Drug Administration 240-402-7592
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