Library of Integrated Network-Based Cellular Signatures (LINCS): Perturbation-Induced Data and Signature Generation Centers (U54)

The summary for the Library of Integrated Network-Based Cellular Signatures (LINCS): Perturbation-Induced Data and Signature Generation Centers (U54) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.
Library of Integrated Network-Based Cellular Signatures (LINCS): Perturbation-Induced Data and Signature Generation Centers (U54): This FOA seeks to establish a large-scale data production effort to systematize approaches for identifying mechanism-based associations between the effects of disparate biological perturbations, by means of signatures. Such perturbations may include siRNAs, small bioactive molecules, environmental manipulations, among others. These data will also inform a knowledge base that can be used to study functional relationships among the responding cellular components. The Library of Integrated Network-Based Cellular Signatures (LINCS) program will support high-throughput collection and integrative computational analysis of informative molecular activity and cellular response features applied to a set of carefully selected human cell types. Relevant predictive patterns of molecular activities and other cellular behaviors are the cellular signatures that characterize responses to a variety of perturbing agents. The resulting knowledge-base of signatures will form the basis of a long-lived resource that can be used broadly by the community. For example, LINCS may inform the association of disease states with detailed molecular or cellular phenotypes caused by specific genetic variants, relating disease with changes in the function of specific gene networks, or the mechanism of action of known drugs. This FOA seeks to fund large-scale data production efforts that will enhance the existing LINCS resource while addressing the following: use of a broader range of cell types and assays than used in the existing LINCS resource, improved multidimensional data integration, some new technology development, user-interfaces needed by the typical biomedical scientist, and dissemination of the LINCS approach to study a broad range of disease biology and mechanisms. The outcomes of the research solicited by this FOA are expected to be highly synergistic with those of other research programs.
Federal Grant Title: Library of Integrated Network-Based Cellular Signatures (LINCS): Perturbation-Induced Data and Signature Generation Centers (U54)
Federal Agency Name: National Institutes of Health
Grant Categories: Health
Type of Opportunity: Discretionary
Funding Opportunity Number: RFA-RM-13-013
Type of Funding: Cooperative Agreement
CFDA Numbers: 93.310
CFDA Descriptions: Trans-NIH Research Support
Current Application Deadline: Dec 19, 2013
Original Application Deadline: Dec 19, 2013
Posted Date: Aug 19, 2013
Creation Date: Aug 19, 2013
Archive Date: Jan 19, 2014
Total Program Funding: $10,000,000
Maximum Federal Grant Award: $1,700,000
Minimum Federal Grant Award: none
Expected Number of Awards:
Cost Sharing or Matching: No
Applicants Eligible for this Grant
Private institutions of higher education
Public and State controlled institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)
City or township governments
Special district governments
Independent school districts
For profit organizations other than small businesses
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Public housing authorities/Indian housing authorities
State governments
County governments
Small businesses
Native American tribal governments (Federally recognized)
Additional Information on Eligibility
Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Link to Full Grant Announcement
Grant Announcement Contact
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National Institutes of Health 301-496-3405
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