Mechanisms of Alcoholic and Nonalcoholic Fatty Liver (Steatosis)

The summary for the Mechanisms of Alcoholic and Nonalcoholic Fatty Liver (Steatosis) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.
Mechanisms of Alcoholic and Nonalcoholic Fatty Liver (Steatosis): - The National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and Office of Dietary Supplements (ODS) of the National Institutes of Health (NIH) invite research grant applications that will employ an integrative approach using state-of-the-art technologies to gain insight into the molecular and biochemical mechanisms of alcoholic and nonalcoholic fatty liver. This announcement addresses several areas considered to be high priority for liver disease research as delineated in the recently published Trans-NIH Action Plan for Liver Disease Research (http://liverplan.niddk.nih.gov), specifically in the area of fatty liver disease. The areas of focus include investigations of mechanisms by which alcohol and nonalcoholic physiologic processes: a) accelerate import of free fatty acids into hepatocytes; b) impair mitochondrial a-oxidation of fatty acids; c) impede the entry of fre! e fatty acids into mitochondria; d) promote de novo fatty acid synthesis; e) promote esterification of free fatty acids into triglycerides; and f) disrupt export of triglycerides from hepatocytes. Research to develop non-invasive biomarkers for fatty liver using genomics, proteomics, and metabolomics, is also encouraged. Proposals investigating the modulating effects of dietary fatty acids, obesity, diabetes, insulin resistance, and components of the metabolic syndrome on alcoholic and nonalcoholic fatty liver are also encouraged. Understanding these mechanisms may help develop strategies for the prevention of accumulation of fat within the liver which may block or delay the progression of fatty liver to active hepatitis, fibrosis, and cirrhosis. - Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. - This PA will use the NIH R01, R21 and R03 mechanisms. - Organizations that are eligible for this program include domestic non-profit organizations; public or private institutions, such as universities, colleges, hospitals, and laboratories; units of state and local governments; and eligible agencies of the Federal government. - Eligible principal investigators include any individuals with the skills, knowledge, and resources necessary to carry out the proposed research. - Applicants may submit more than one application, provided they are scientifically distinct. - See Section IV.1 for application materials. - Telecommunications for the hearing impaired is available at: TTY 301-451-0088
Federal Grant Title: Mechanisms of Alcoholic and Nonalcoholic Fatty Liver (Steatosis)
Federal Agency Name: National Institutes of Health
Grant Categories: Food and Nutrition Health
Type of Opportunity: Discretionary
Funding Opportunity Number: PA-05-119
Type of Funding: Grant
CFDA Numbers: 93.27393.848
CFDA Descriptions: Alcohol Research Programs 93.848 Digestive Diseases and Nutrition Research
Current Application Deadline: No deadline provided
Original Application Deadline: Multiple Receipt Dates - See Link to Full Announce
Posted Date: Jun 10, 2005
Creation Date: Nov 20, 2006
Archive Date: Feb 03, 2007
Total Program Funding:
Maximum Federal Grant Award:
Minimum Federal Grant Award:
Expected Number of Awards:
Cost Sharing or Matching: No
Applicants Eligible for this Grant
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education State governments City or township governments Others (see text field entitled "Additional Information on Eligibility" for clarification) Public housing authorities/Indian housing authorities For profit organizations other than small businesses Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Public and State controlled institutions of higher education County governments Independent school districts
Additional Information on Eligibility
Eligible agencies of the Federal Government are eligible to apply. Foreign institutions are eligible to apply.
Link to Full Grant Announcement
Information not provided
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