Optimization of Small Molecule Probes for the Nervous System (STTR [R41])

The summary for the Optimization of Small Molecule Probes for the Nervous System (STTR [R41]) Federal Grant is detailed below. It contains information such as the Catalog of Federal Domestic Assistance (CFDA) number, who is eligible for the grant, how much grant money will be awarded, important deadlines, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed in the Grant Announcement Contact section. If these sections are incomplete, please visit the website of the government agency that is offering this grant.


	Federal Grant Title:	Optimization of Small Molecule Probes for the Nervous System (STTR [R41])
	CFDA Number:	93.273
	CFDA Description:	Alcohol Research Programs
	Federal Agency Name:	National Institutes of Health
	Category of Funding Activity:	Education Health
	Category Explanation:	Information not provided
	Opportunity Category:	Discretionary
	Funding Opportunity Number:	PAR-09-259
	Document Type:	Grants Notice
	Funding Instrument Type:	Grant
	Posted Date:	Aug 26, 2009
	Creation Date:	Aug 26, 2009
	Original Closing Date for Applications:	Sep 07, 2012
	Current Closing Date for Applications:	Sep 07, 2012
	Archive Date:	Oct 08, 2012
	Expected Number of Awards:	Information not provided
	Estimated Total Program Funding:	Information not provided
	Federal Grant Award Ceiling:	$150,000
	Federal Grant Award Floor:	Information not provided
	Cost Sharing or Matching Requirement:	No

Applicants Eligible for this Grant: Small businesses
Additional Information on Eligibility: Information not provided
Grant Description: Purpose This Funding Opportunity Announcement (FOA) encourages Small Business Technology Transfer (STTR) grant applications from small business concerns (SBCs) that propose to develop new small molecule probes for investigating biological function in the nervous system via the application of advanced medicinal chemistry and the biological testing of compounds. Eligible SBCs will have identified probe candidates via screening of small molecule collections, using in vitro assays of biological activity developed to interrogate these collections, and be able to show that the structural features of these small molecules are related to their biological activity. Applications should nominate small molecule probe candidates from distinct structural series for the further, iterative design and testing of analogues in structure-activity relationship studies, using in vitro assays of biological function adapted to the medium throughput screening requirements of this work. These studies should have the goal of developing a small molecule probe possessing the attributes (eg: affinity, selectivity, activity) required for its use in future pharmacological studies proposed by the SBC. Applicants are strongly encouraged to utilize publicly available cheminformatic capabilities for the acquisition of compounds, and semi-custom synthesis of analogues, which is required of these studies. Mechanism of Support. This FOA will utilize the STTR (R41) grant mechanism for Phase I, and runs in parallel with FOAs of identical scientific scope that encourage applications under the Small Business Innovation Research (SBIR) (R43) grant mechanism (PAR-09-260, and the R21 grant mechanism (PAR-09-251). Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. The total amount awarded and the number of awards will depend upon the quality, duration, and costs of the applications received.
Link to Full Grant Announcement: http://grants.nih.gov/grants/guide/pa-files/par-09-259.html
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