Orthopaedic Trauma Research Program-2007 Supplement to BAA 06-1

The summary for the Orthopaedic Trauma Research Program-2007 Supplement to BAA 06-1 grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the Dept of the Army USAMRAA, which is the U.S. government agency offering this grant.

Orthopaedic Trauma Research Program-2007 Supplement to BAA 06-1: Department of Defense (DOD)U.S. Army Institute of Surgical ResearchOrthopaedic Trauma Research Program-2007Call for Pre-ProposalsBroad Agency Announcement (BAA) 06-1 SupplementThe majority of the trauma that occurs in Operation Iraqi Freedom and Operation Enduring Freedom is orthopaedic-related, particularly involving the upper and lower extremities. In an effort to provide better treatment and outcomes from these injuries, the Orthopaedic Trauma Research Program (OTRP) was created. The OTRP is part of the Medical Research and Materiel Commands medical research program and will fund both peer-reviewed intramural and extramural orthopaedic trauma research. The purpose of OTRP is to complement, expand, and broaden the research in orthopaedic trauma that is currently funded by the Department of Defense, National Institutes of Health, and industry. This is directed towards improvement of clinical outcomes in combat casualties.Proposals should be goal-oriented with clearly defined milestones and endpoints and should address the Research Topic Areas of Interest. Multi-year studies are permitted but must have annual milestones. Follow-on funding will be based on the success at the annual milestone and the availability of funding. Translational and clinical research proposals are strongly encouraged. Basic science proposals will be considered but must demonstrate future clinical significance. Translational research and clinical studies should utilize relevant trauma models and patient populations. The strongest consideration will be given to proposals that can improve the care of battlefield-injured soldiers within five years by providing an improved treatment, product, or change of guidelines. Military and civilian collaboration is encouraged. Academic, industry, and government organizations are encouraged to apply. Pre-proposals and proposals will be evaluated using the following criteria: . Military Relevance . Military Impact . Scientific Merit The instructions for submitting a pre-proposal are easily accessible on the USAMRAA website http://www.usamraa.army.mil. Once on the USAMRAA site select the BAA button on the left-central area of the page. This button will lead to the BAA selection page. Select the USAMRMC radio button link and click the Continue button. The instructions and forms necessary for this submission are available at this location. The information listed below is to guide prospective investigators on the focus of this program. Pre-proposals are due no later than 5 p.m. May 8, 2007. You may submit earlier than May 8, 2007, and you are encouraged strongly to do so. The pre-proposal electronic form is located at http://www.usamraa.army.mil/pages/baa_forms/user/login.cfm. Please select "OTRP from the "Program" pull-down menu and provide requested information. An e-mail will acknowledge receipt of your pre-proposal. Pre-proposals will be reviewed in order to identify proposals aligned with the OTRP priorities. Invitations to submit a full proposal will be sent to the principal investigators whose pre-proposals are selected for further consideration. DO NOT submit a full proposal unless you receive a letter of invitation. Performance periods should not exceed four years, and total cost including indirect costs should not exceed $500,000 per year unless permission has been granted. Questions related to FY07 OTRP Call for Pre-Proposals, please contact: [email protected] or call the USAISR OTRP Program Administrator at: 210-916-9426.Anticipated Instrument Type(s): The USAMRMC implements its extramural research program predominantly through the award of grants and cooperative agreements. More information on these funding instruments may be obtained by request from:FAX: 301-619-2937 and Email:[email protected] to be aware of are: 1. Pre-proposal Deadline: 5:00 p.m. Eastern Time, May 8, 2007 2. Proposal Submission Deadline: 11:59 p.m. Eastern Time, June 19, 20073. Required Supporting Documents: 11:59 p.m. Eastern Time, June 19, 2007Below are the research topics of interest. Each topic is noted with the suggested research discipline.Research Topic Areas of Interest (b=basic, t=translational, and c=clinical): Improved Healing of Segmental Bone Defects (t,c) Develop a treatment for fractures likely to become non-unions due to the size of the defect, concomitant neural/vascular injury, or lack of soft tissue coverage. Tissue engineering or regenerative medicine approaches to discover treatments that are capable of working in the face of contamination / infection are desired.Reduction in Wound Infection (c) Develop devices, technologies, and treatments to prevent or treat infections in bone and soft tissue traumatic injuries. Potential grantees should be aware of the challenges and organisms which are of interest in military casualties. Treatments should be effective against methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella. Prevention of Heterotopic Ossification (b,t,c) Retrospective analysis of trauma records indicates that heterotopic ossification is a more common sequelae in combat casualty injuries than in civilian trauma cases. The extent of injury, the mechanism of injury, and attempts to preserve limb length through the zone of injury are suspected to play a role. Describe the mechanisms of the disease, develop a means of minimizing the disease process while allowing normal healing to occur, or determine the burden of the disease. Improved Healing of Massive Soft Tissue Defects (t,c) Develop a treatment through tissue engineering or regenerative medicine technologies to improve healing and return function to patients who have sustained a significant loss of muscle tissue, nerve, blood vessels, or skin. Tissue Viability Assessment and Wound Irrigation / Debridement Technologies (t,c) Develop systems or evidence-based guidelines for the assessment of injured tissue and optimal timing and techniques of irrigation and debridement that will reduce infection rates. Translating Research into Practice(c)Implement innovative research methods to evaluate the translation of orthopaedic trauma research into clinical practice that result in measurable improvements in clinical outcomes. Three specific priorities for these projects are: 1. Determine the extent of evidence-based medicine that is being performed in the orthopaedic trauma community. Emphasis should be on the military population or injuries that are relevant to the military population.2. Compare the use of various interventions that successfully translate orthopaedic trauma research findings into practice.3. Measure the impact of translation activities and interventions that foster measurable and sustainable quality and patient safety improvement or consistent quality and patient safety at a lower cost.