Pilot and Feasibility Program in Human Islet Biology
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Federal Grant Title:
PILOT AND FEASIBILITY PROGRAM IN HUMAN ISLET BIOLOGY
State governments County governments City or township governments Special district governments Independent school districts Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education For profit organizations other than small businesses Small businesses Others (see text field entitled "Additional Information on Eligibility" for clarification)
Additional Information on Eligibility
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Much of our understanding of the basic biology and function of the beta cell and the pancreatic islet comes from studies of immortalized cell lines and mouse tissue. However, differences in the general structure and organization of mouse and human islets have been identified, and it remains uncertain if these structural differences reflect functional differences as well. With the variable success in islet transplantation and the inability to use in vitro data to reliably predict islet engraftment and function, it is important to learn all that we can about the structure, organization, and signaling properties of human islets, and to compare and contrast these findings with those reported with rodent models of islet function used to date. The information gained from these studies should increase our ability to develop new reagents for use in in vivo imaging studies of the human islet, to develop fingerprinting assays for use in predicting human islet transplant success, and to further develop cellular therapies for potential use in the treatment of type 1 diabetes.