Stress Pathways in Alcohol Induced Organ Injury and Protection (R21)

The summary for the Stress Pathways in Alcohol Induced Organ Injury and Protection (R21) Federal Grant is detailed below. It contains information such as the Catalog of Federal Domestic Assistance (CFDA) number, who is eligible for the grant, how much grant money will be awarded, important deadlines, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed in the Grant Announcement Contact section. If these sections are incomplete, please visit the website of the government agency that is offering this grant.


	Federal Grant Title:	Stress Pathways in Alcohol Induced Organ Injury and Protection (R21)
	CFDA Number:	93.701
	CFDA Description:	Trans-NIH Recovery Act Research Support
	Federal Agency Name:	National Institutes of Health
	Category of Funding Activity:	Health
	Category Explanation:	Information not provided
	Opportunity Category:	Discretionary
	Funding Opportunity Number:	PA-10-094
	Document Type:	Grants Notice
	Funding Instrument Type:	Grant
	Posted Date:	Mar 17, 2010
	Creation Date:	Mar 17, 2010
	Original Closing Date for Applications:	May 07, 2013
	Current Closing Date for Applications:	May 07, 2013
	Archive Date:	Jun 07, 2013
	Expected Number of Awards:	Information not provided
	Estimated Total Program Funding:	Information not provided
	Federal Grant Award Ceiling:	$200,000
	Federal Grant Award Floor:	Information not provided
	Cost Sharing or Matching Requirement:	No

Applicants Eligible for this Grant: State governments - County governments - City or township governments - Special district governments - Independent school districts - Public and State controlled institutions of higher education - Native American tribal governments (Federally recognized) - Public housing authorities/Indian housing authorities - Native American tribal organizations (other than Federally recognized tribal governments) - Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education - Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education - Private institutions of higher education - For profit organizations other than small businesses - Small businesses - Others (see text field entitled "Additional Information on Eligibility" for clarification)
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Grant Description: Purpose. This Funding Opportunity Announcement (FOA) issued by the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, encourages Research Project Grant (R21) applications that propose studying the role of cellular stress responses, the cytoplasmic classical stress response or heat shock response (HSR) and the endoplasmic reticulum (ER) stress, in alcohol-induced tissue injury and tissue protection. While excessive alcohol use causes organ damage, moderate alcohol consumption may be beneficial. The underlying molecular mechanisms for this apparent dichotomy of alcohols harmful and salutary effects are currently not fully understood. Alcohol induces cellular stress pathways in the cytoplasm and in the endoplasmic reticulum that may significantly be involved in alcohol-induced tissue injury or mediate tissue protection depending on the quantity, frequency, duration, and temporal pattern of drinking. Hence, studies of the effects of alcohol on cellular stress pathways are critical to understand the mechanisms of alcohol-induced injuries or protection to develop new strategies for prevention, diagnosis and treatment. The purpose of this FOA is to: (1) acquire insight into how acute or chronic alcohol consumption affects cellular stress pathways and in turn, how these changes contribute to alcohol-induced injury/protection; (2) investigate how alcohol induced stress responses mediate cell survival and death signaling pathways at macromolecular, organelle, cellular and organism level contributing to alcohol-induced tissue injury/protection; (3) develop potential stress related biomarkers for prognosis, diagnosis of tissue injury/protection, furthermore identify new targets for their therapeutic interventions. Utilizing innovative experimental design and emerging technologies, such as deep sequencing, genomics, proteomics, metabolomics, bioinformatics, and novel imaging techniques these investigations are expected to provide a more comprehensive understanding of how alcohol affects the evolutionally conserved stress pathways and elucidate their roles in tissue injuries and repair Mechanism of Support. This FOA will use the NIH Exploratory/Developmental (R21) award mechanism and runs in parallel with a FOA of identical scientific scope, PA-10-093, that encourages applications under the R01 mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.
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