Studies of Antimicrobial and Prebiotic Activity of Oligosaccharides (R01)

The summary for the Studies of Antimicrobial and Prebiotic Activity of Oligosaccharides (R01) Federal Grant is detailed below. It contains information such as the Catalog of Federal Domestic Assistance (CFDA) number, who is eligible for the grant, how much grant money will be awarded, important deadlines, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed in the Grant Announcement Contact section. If these sections are incomplete, please visit the website of the government agency that is offering this grant.


	Federal Grant Title:	Studies of Antimicrobial and Prebiotic Activity of Oligosaccharides (R01)
	CFDA Number:	93.865
	CFDA Description:	Child Health and Human Development Extramural Research
	Federal Agency Name:	National Institutes of Health
	Category of Funding Activity:	Health Income Security and Social Services
	Category Explanation:	Information not provided
	Opportunity Category:	Discretionary
	Funding Opportunity Number:	RFA-HD-08-004
	Document Type:	Grants Notice
	Funding Instrument Type:	Grant
	Posted Date:	Jan 11, 2008
	Creation Date:	Jan 11, 2008
	Original Closing Date for Applications:	Nov 14, 2008
	Current Closing Date for Applications:	Information not provided
	Archive Date:	Dec 15, 2008
	Expected Number of Awards:	Information not provided
	Estimated Total Program Funding:	$2,500,000
	Federal Grant Award Ceiling:	Information not provided
	Federal Grant Award Floor:	Information not provided
	Cost Sharing or Matching Requirement:	No

Applicants Eligible for this Grant: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled "Additional Information on Eligibility" for clarification) For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Private institutions of higher education Small businesses
Additional Information on Eligibility: Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith-based or community-based organizations can apply.
Grant Description: Purpose. The National Institute of Child Health and Human Development, National Institutes of Health, solicits Research Project Grant (R01) applications from institutions/organizations that propose to elucidate the antimicrobial and prebiotic activities of oligosaccharides and glycoconjugates. The goal of this FOA is to stimulate research on how oligosaccharides prevent enteric infections and to develop a new class of antimicrobial therapy to prevent or treat enteric bacterial or viral infections. A key step in reaching this goal is to develop biosynthetic means of producing large enough quantities of oligosaccharides with antimicrobial properties for preclinical tolerance and safety studies and for safety and clinical testing in populations that are exposed to gastrointestinal pathogens. This FOA should also stimulate research on the expression of genes in the host that determine oligosaccharide assembly and linkage. This line of research should lead to a better understanding of the how oligosaccharide binding sites for specific enteric pathogens are synthesized, packaged, transported, and incorporated into the cell membrane of the enterocyte. By knowing more about oligosaccharide structures of pathogen binding sites on the surface of the enterocyte, it may be possible to predict which individuals are susceptible to specific bacterial and viral infections and to develop antimicrobial agents based on oligosaccharide structural mimicry of these pathogen binding sites. This FOA should also encourage research on oligosaccharides that stimulate the proliferation of beneficial intestinal bacteria and the production of short-chain fatty acids, thereby serving to reduce the incidence and severity of enteric infections. Studies on the immunomodulatory effects of various oligosaccharides on the function of the intestinal immune system are also encouraged. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. Funds Available and Anticipated Number of Awards. $2,500,000 has been set aside in total direct costs to fund this initiative in FY 2009. It is anticipated that 5-8 awards will be made. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. Eligible Institutions/Organizations. Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; Non-domestic (non-U.S.) Entity (Foreign Organization); Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Eligible agencies of the Federal government; Faith-based or community based organizations. Eligible Project Directors/Principal Investigators (PDs/PIs). Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution/organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. Number of Applications. Applicants may submit more than one application, provided each application is scientifically distinct. Renewals and Resubmissions. At this time, it is not known if competing renewal (formerly competing continuation ) applications will be accepted and/or if this FOA will be reissued. Applicants may submit a resubmission application, but such application must include an Introduction addressing the previous peer review critique (Summary Statement). Number of PDs/PIs. More than one PD/PI, or multiple PDs/PIs, may be designated on the application.
Link to Full Grant Announcement: http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-08-004.html http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-08-004.html
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