Systems Biology Approach to the Mechanisms of TB Latency and Reactivation (R01)

The summary for the Systems Biology Approach to the Mechanisms of TB Latency and Reactivation (R01) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.
Systems Biology Approach to the Mechanisms of TB Latency and Reactivation (R01): Purpose. The National Heart, Lung, and Blood Institute solicits Research Project Grant (R01) applications under this funding opportunity announcement (FOA) to investigate the mechanisms of latency and the reactivation of tuberculosis in the host using integrated systems biology approaches. Systems biology is defined in many ways. For the purposes of this FOA we are using a definition found on the MIT CSBi website: research program that links biologists, computer scientists, and engineers in a multi disciplinary approach to the systematic analysis of complex biological phenomena. The studies should include multiscale computational modeling and focus on host lung responses to Mycobacterium tuberculosis (Mtb) and host-microbial interactions that drive latency and reactivation in humans. To build the theoretical models, human and animal data should be utilized. The studies should integrate the data obtained from omic approaches with biological/immunological data. The models should be such that they can be tested in humans or non-human primates. The use of human samples and or data is required. Applicants are strongly encouraged to use the multiple principal investigator mechanism to facilitate collaborations among investigators with expertise in mathematics and computational multiscale modeling and clinical investigators and experimental biologists who have expertise in tuberculosis, pulmonology, lung biology, immunology, microbiology, genomics, genetics, other omics, and infectious diseases. Applicants are also strongly urged to include bioengineers and physicists in the research groups to enable teams of investigators to take advantage of new and developing technologies likely to be needed both to obtain biological data for building the computational models and for testing hypotheses generated by them. This FOA solicits applications for the TB Systems Biology Centers and runs in parallel with a separate FOA that solicits applications for a Data Coordinating Center (see RFA-HL-10-022).
Federal Grant Title: Systems Biology Approach to the Mechanisms of TB Latency and Reactivation (R01)
Federal Agency Name: National Institutes of Health
Grant Categories: Health
Type of Opportunity: Discretionary
Funding Opportunity Number: RFA-HL-10-015
Type of Funding: Grant
CFDA Numbers: 93.838
CFDA Descriptions: Lung Diseases Research
Current Application Deadline: Mar 24, 2010
Original Application Deadline: Mar 24, 2010
Posted Date: Dec 09, 2009
Creation Date: Dec 09, 2009
Archive Date: Apr 24, 2010
Total Program Funding: $3,450,000
Maximum Federal Grant Award: $250,000
Minimum Federal Grant Award:
Expected Number of Awards:
Cost Sharing or Matching: No
Applicants Eligible for this Grant
State governments - County governments - City or township governments - Special district governments - Independent school districts - Public and State controlled institutions of higher education - Native American tribal governments (Federally recognized) - Public housing authorities/Indian housing authorities - Native American tribal organizations (other than Federally recognized tribal governments) - Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education - Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education - Private institutions of higher education - For profit organizations other than small businesses - Small businesses - Others (see text field entitled "Additional Information on Eligibility" for clarification)
Additional Information on Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Link to Full Grant Announcement
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