The Role of Apolipoprotein E, Lipoprotein Receptors and CNS Lipid Homeostasis in Brain Aging and Alzheimers Disease (R01)

The summary for the The Role of Apolipoprotein E, Lipoprotein Receptors and CNS Lipid Homeostasis in Brain Aging and Alzheimers Disease (R01) Federal Grant is detailed below. It contains information such as the Catalog of Federal Domestic Assistance (CFDA) number, who is eligible for the grant, how much grant money will be awarded, important deadlines, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed in the Grant Announcement Contact section. If these sections are incomplete, please visit the website of the government agency that is offering this grant.


	Federal Grant Title:	The Role of Apolipoprotein E, Lipoprotein Receptors and CNS Lipid Homeostasis in Brain Aging and Alzheimers Disease (R01)
	CFDA Number:	93.866
	CFDA Description:	Aging Research
	Federal Agency Name:	National Institutes of Health
	Category of Funding Activity:	Health
	Category Explanation:	Information not provided
	Opportunity Category:	Discretionary
	Funding Opportunity Number:	PA-09-217
	Document Type:	Grants Notice
	Funding Instrument Type:	Grant
	Posted Date:	Jul 06, 2009
	Creation Date:	Jul 06, 2009
	Original Closing Date for Applications:	Sep 07, 2012
	Current Closing Date for Applications:	Sep 07, 2012
	Archive Date:	Oct 08, 2012
	Expected Number of Awards:	Information not provided
	Estimated Total Program Funding:	$2,500,000
	Federal Grant Award Ceiling:	Information not provided
	Federal Grant Award Floor:	Information not provided
	Cost Sharing or Matching Requirement:	No

Applicants Eligible for this Grant: State governments - County governments - City or township governments - Special district governments - Independent school districts - Public and State controlled institutions of higher education - Native American tribal governments (Federally recognized) - Public housing authorities/Indian housing authorities - Native American tribal organizations (other than Federally recognized tribal governments) - Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education - Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education - Private institutions of higher education - For profit organizations other than small businesses - Small businesses - Others (see text field entitled "Additional Information on Eligibility" for clarification)
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Grant Description: Purpose. This FOA encouarges multidisciplinary and interdisciplinary research to elucidate how Apolipoprotein E, lipoprotein receptors and CNS lipid homeostasis influence brain aging and the transition to neurodegeneration in Alzheimers disease (AD). The ultimate goal is to gain an in depth understanding of the mechanisms by which the Apolipoprotein E e4 allele confers increased AD risk for the purpose of advancing the overall search for efficacious AD treatments and Apolipoprotein E e4-directed therapeutics in particular. To this end we encourage research spanning multiple levels of analysis in multiple species (from mice to man).Studies aimed at identifying new therapeutic targets for the treatment of AD and other age-related neurodegenerative conditions associated with lipid neurobiology are strongly encouraged. Also of great interest are projects that aim to use lipidomics, various types of imaging and other cutting edge technologies to identify and develop early biomarkers of neurodegeneration associated lipid dyshomeostasis. Mechanism of Support. This FOA will utilize the R01 grant mechanism. Funds Available and Anticipated Number of Awards. During Fiscal Year 2010, the estimated amount of funds available to support projects under this FOA is $2,500,000.Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary.Given the likely range of budgets, it is anticipated that 4 to 7 awards could be made during Fiscal Year 2010.The availability of funds and the number of awards in future years will depend upon annual appropriations.
Link to Full Grant Announcement: http://grants.nih.gov/grants/guide/pa-files/pa-09-217.html
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