The Role of Mitochondria in Alcohol-Induced Tissue Injury (R21)

The summary for the The Role of Mitochondria in Alcohol-Induced Tissue Injury (R21) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.

The Role of Mitochondria in Alcohol-Induced Tissue Injury (R21): Purpose. Excessive alcohol consumption can damage many organ systems including the liver, heart, pancreas, brain, and lung. However, the mechanisms for these alcohol-induced tissue injuries are currently not fully understood. Mitochondria play an important role in cellular functions and are significantly involved in alcohol-induced tissue injury. Thus, studies of alcohol s effects on mitochondrial structure and function are critical to better understand the mechanisms of alcohol-induced injuries and to develop new strategies for their diagnosis and treatment. The purpose of this FOA is to (1) better understand how acute or chronic alcohol consumption affects mitochondrial structure and function, and in turn, how these mitochondrial changes contribute to the alcohol-induced injuries; (2) investigate how pre-existing variations in the mitochondrial proteins, either mitochondria- or nuclear-encoded, or in the control of their expression or function, including cellular signaling pathways, contribute to an individual s response to acute or chronic alcohol intake and tissue injuries; (3) develop potential biomarkers for prognosis and diagnosis of tissue injury, or identify new targets for therapeutic interventions of alcohol-induced tissue injuries. This FOA aims to foster the utilization of innovative experimental design and emerging technologies, such as genomics, proteomics, metabolomics, bioinformatics, as well as novel microscopic imaging techniques that illuminate mitochondrial function in intact cells and tissues, to generate new mechanistic and clinical insights into alcohol-induced tissue injuries.

Federal Grant Title:	The Role of Mitochondria in Alcohol-Induced Tissue Injury (R21)
Federal Agency Name:	National Institutes of Health
Grant Categories:	Health
Type of Opportunity:	Discretionary
Funding Opportunity Number:	RFA-AA-08-001
Type of Funding:	Grant
CFDA Numbers:	93.273
CFDA Descriptions:	Alcohol Research Programs
Current Application Deadline:	No deadline provided
Original Application Deadline:	Oct 31, 2007
Posted Date:	May 25, 2007
Creation Date:	May 25, 2007
Archive Date:	Nov 30, 2007
Total Program Funding:	$2,000,000
Maximum Federal Grant Award:
Minimum Federal Grant Award:
Expected Number of Awards:
Cost Sharing or Matching:	No

Applicants Eligible for this Grant: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Private institutions of higher education County governments Special district governments State governments Public housing authorities/Indian housing authorities Small businesses Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Public and State controlled institutions of higher education Others (see text field entitled "Additional Information on Eligibility" for clarification) Independent school districts For profit organizations other than small businesses
Additional Information on Eligibility: Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith-based or community-based organizations can apply.
Link to Full Grant Announcement: Information not provided
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