Cancer Intervention and Surveillance Modeling Network (Cisnet)

The summary for the Cancer Intervention and Surveillance Modeling Network (Cisnet) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.
Cancer Intervention and Surveillance Modeling Network (Cisnet): The Division of Cancer Control and Population Sciences (DCCPS), National Cancer Institute (NCI), invites applications from domestic and foreign applicants to support collaborative research using simulation and other modeling techniques to describe the impact of interventions (i.e., primary prevention, screening, and treatment) in population- based settings in the United States or in non-US settings that will shed light on US population-based trends. It is well known that great progress in the war against cancer is possible by the complete use and adequate delivery of existing modalities of cancer control. The primary goals of this research are: 1) to determine the impact of cancer control interventions on observed trends in incidence and/or mortality; and 2) to determine if recommended interventions are having their expected population impact by examining discrepancies between controlled cancer intervention study results and the population experience. Once a general understanding of the various factors influencing current trends has been achieved, a number of secondary goals may be addressed. Applicants may propose secondary goals of modeling the potential impact of new interventions on future national trends, and/or determining the impact of targeted cancer control interventions on population outcome (i.e. evaluating optimal cancer control strategies). Prior to the first issuance of CISNET most models of cancer interventions had been developed to describe hypothetical cohorts in a trial or other limited clinical settings. It is not the purpose of this RFA to focus on the analysis of hypothetical or trial-based cohorts and/or cost-effectiveness analyses, but rather to support analyses based on realistic scenarios of population impact. Projects will focus on models describing the population impact of the observed dissemination of cancer control interventions as well as other factors on observed national incidence and/or mortality trends. CISNET was originally funded as a cooperative agreement (U01) for two phased-in rounds of funding. In September 2000, CA-99-013 funded seven grants in breast cancer and one in prostate and one in colorectal cancer. A second round, funded under CA-02-010 in August 2002, funded 5 grants in lung cancer as well as two additional grants for colorectal cancer and one in prostate cancer. The first round of funding will end in September 2004, and the second round in summer/fall 2006. For a summary of currently funded CISNET projects from the first and second rounds of funding (which started in FY 2000 and 2002 respectively) cancer see This reissuance of CISNET will be limited to modeling applications focusing on breast, prostate, lung, and colorectal cancer. While the reissuance of CISNET will not be limited to grantees previously or currently funded, CISNET will no longer fund models that are either starting from scratch or have not been previously applied to the analysis of population trends. This means that models should have been applied to multiple real birth cohorts representing the actual population experience. Models that have been applied only to hypothetical cohorts, as is sometimes done to model trial data or estimate cost effectiveness, will not be considered. The emphasis in this reissuance is in the application of already developed models to study the population impact of existing or emerging cancer control interventions. Applicants who were funded by either CA-99-013 or CA- 02-010 are eligible to apply for funding, as well as those who have never been funded under a CISNET RFA. In addition, applications are being solicited for cancer site-specific coordinating centers for all four of the cancer sites covered in CISNET (i.e. breast, prostate, colorectal and lung cancer). To keep applications focused, each will be limited to a single cancer site. The CISNET project requirements call for the development of site-specific working groups that will: (1) facilitate comparative analyses, (2) allow modeling groups access to a broader array of data resources and interdisciplinary expertise and (3) provide a forum for discussions of validation and other methodologic issues. The CISNET will allow for diversity and originality of modeling approaches that can be compared using uniform criteria. New investigators will be expected to join in the ongoing collaborative activities already underway. The Division of Cancer Control and Population Sciences, which fulfills a federal-level function to respond to evolving surveillance questions of national policy relevance, helps focus research questions and acts as a conduit to national data resources necessary for parameter estimation, model calibration, validation and population trends. An emergent property of this collaborative agreement is progress towards a comprehensive understanding of the determinants of cancer site-specific trends at the population level and a better understanding of the science of modeling.
Federal Grant Title: Cancer Intervention and Surveillance Modeling Network (Cisnet)
Federal Agency Name: National Institutes of Health
Grant Categories: Health Education
Type of Opportunity: Discretionary
Funding Opportunity Number: RFA-CA-05-018
Type of Funding: Cooperative Agreement
CFDA Numbers: 93.39393.394
CFDA Descriptions: Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research
Current Application Deadline: No deadline provided
Original Application Deadline: Oct 14, 2004
Posted Date: May 17, 2004
Creation Date: May 17, 2004
Archive Date: Nov 13, 2004
Total Program Funding:
Maximum Federal Grant Award:
Minimum Federal Grant Award:
Expected Number of Awards:
Cost Sharing or Matching: No
Applicants Eligible for this Grant
State governments County governments City or township governments Special district governments Independent school districts Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education For profit organizations other than small businesses Small businesses
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