Centers for Evaluation of Neurodevelopmental Antibodies (CENA, U24)

The summary for the Centers for Evaluation of Neurodevelopmental Antibodies (CENA, U24) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.
Centers for Evaluation of Neurodevelopmental Antibodies (CENA, U24): Purpose: The goal of this initiative is to create a center (or centers) to 1) evaluate new monoclonal antibodies (mABs) to neurodevelopmental antigens using multiple model systems and 2) provide detailed information for use of these reagents to the research community. Some of the most powerful tools in understanding nervous system development are antibodies that monitor the expression of key developmental proteins. Accordingly, one of the most compelling needs within the community is greater access to well-validated mABs. As an initial step to address this need, the NIH Blueprint for Neuroscience Research (subsequently referred to as the Blueprint) is currently funding the targeted creation and distribution of a large number of high quality monoclonal antibodies via the Blueprint Resource Antibodies Initiative for Neurodevelopment (BRAINdev) in partnership with the UC Davis/NINDS/NIMH NeuroMab Facility ( An important component of the overall Blueprint mAB plan is to provide detailed information on the performance of the antibodies across model systems common to neurodevelopmental research. While BRAINdev antibodies will initially be assayed in a limited number of model organisms via NeuroMab, their utility in a broad range model systems will be evaluated by a associated, but distinct center(s) to be called the Center(s) for Neurodevelopmental Antibodies (CENA). All of the BRAINdev antibodies, and all of the evaluation data produced by the centers, will be made available to the research community. To fulfill the evaluation portion of this plan, this Funding Opportunity Announcement (FOA) solicits applications directed toward the creation of a center (or centers) to perform further examination of mABs immunoreactivity in the developing central and peripheral nervous systems of multiple model systems. This announcement specifically requests the creation of antibody evaluation centers which will, in total, determine the ability of antibodies to recognize their corresponding antigen during development in the following organisms: fruit fly (D. melanogaster), nematode (C. elegans), zebrafish (D. rerio), mouse (M. musculus), chick (G. gallus), frog (X. laevis and X. tropicalis), rat (R. norvegicus), rhesus monkey (M. mulatta) and human (H. sapiens). Individual centers will establish experimental conditions for antibody use during development, including immunoblotting, and immunohistochemistry in at least five species, as well as provide these data to the neurodevelopment community. Mechanism of Support. This FOA uses the Resource-Related Research Projects-Cooperative Agreement (U24) award mechanism Funds Available and Anticipated Number of Awards. The Blueprint is a framework to enhance cooperative activities among the NIH Office of the Director and 15 NIH Institutes and Centers (ICs) that support research on the central and peripheral nervous systems. In fiscal year 2008, the Blueprint is emphasizing neural development. The participating Blueprint organizations intend to commit $1,200,000 over a two-year period to fund 1 to 3 applications in response to this FOA. Additional meritorious applications may be funded by individual NIH Institutes. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Budget and Project Period. The total project period for an application submitted in response to this funding opportunity may not exceed two years. Direct costs are limited to $600,000 per year for a two-year period. Eligible Institutions/Organizations. Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); State Government; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Non-domestic (non-U.S.) Entity (Foreign Organization); Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Regional Organization; Eligible agencies of the Federal government. Eligible Project Directors/Principal Investigators (PDs/PIs): Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. Number of Applications. Applicants may submit more than one application, provided each application is scientifically distinct. Renewals and Resubmissions. Neither renewals or resubmissions will be accepted for this FOA. Number of PDs/PIs. More than one PD/PI, or multiple PDs/PIs, may be designated on the application. Application Materials. See Section IV.1 for application materials. Hearing Impaired. Telecommunications for the hearing impaired is available at: TTY 301-451-0088. Initial merit review will be convened by NINDS Special Receipt Date: February 15, 2008
Federal Grant Title: Centers for Evaluation of Neurodevelopmental Antibodies (CENA, U24)
Federal Agency Name: National Institutes of Health
Grant Categories: Income Security and Social Services Health Education Environment
Type of Opportunity: Discretionary
Funding Opportunity Number: RFA-NS-08-005
Type of Funding: Cooperative Agreement
CFDA Numbers: 93.12193.173
CFDA Descriptions: Oral Diseases and Disorders Research 93.173 Research Related to Deafness and Communication Disorders
Current Application Deadline: No deadline provided
Original Application Deadline: Feb 15, 2008
Posted Date: Dec 13, 2007
Creation Date: Dec 13, 2007
Archive Date: Mar 17, 2008
Total Program Funding: $1,200,000
Maximum Federal Grant Award:
Minimum Federal Grant Award:
Expected Number of Awards:
Cost Sharing or Matching: 93.213 -- Research and Training in Complementary and Alternative Medicine
Applicants Eligible for this Grant
State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Others (see text field entitled "Additional Information on Eligibility" for clarification) Special district governments Public housing authorities/Indian housing authorities Independent school districts Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal governments (Federally recognized) County governments Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments
Additional Information on Eligibility
Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply.
Link to Full Grant Announcement
Information not provided
Grant Announcement Contact
NIH OER Webmaster
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