Countermeasures Against Chemical Threats (CounterACT): Identification of Therapeutic Lead Compounds (U01)

The summary for the Countermeasures Against Chemical Threats (CounterACT): Identification of Therapeutic Lead Compounds (U01) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.
Countermeasures Against Chemical Threats (CounterACT): Identification of Therapeutic Lead Compounds (U01): The mission of the NIH Countermeasures Against Chemical Threats (CounterACT) program is to develop new and improved therapeutics to treat and/or prevent injuries resulting from exposure to chemical threats. Chemical threats are toxic chemicals that could be used in a terrorist attack or accidentally released from industrial production, storage or shipping. They include traditional chemical warfare agents and toxic industrial chemicals and materials. This Funding Opportunity Announcement (FOA) requests new research applications for Cooperative Agreement Research Projects (U01s) seeking support for research on the identification of small molecule or biologic lead compounds that are excellent candidates for therapeutic development. The scope of research supported by this FOA includes confirmation of molecular targets for therapeutic development, demonstration of in vitro activity of candidate therapeutics, preliminary in vivo proof-of-concept efficacy data, preliminary adsorption, distribution, metabolism, excretion, and toxicity (ADME/Tox) evaluations and pharmacokinetics/pharmacodynamics (PK/PD) data. These studies should result in the identification of at least one lead compound ready for optimization. Lead compounds are biologically active and synthetically feasible compounds where specificity, affinity, potency, target selectivity, efficacy, and safety have been established. Lead compounds should be ready for more advanced development under possible support from other programs such as the one described in the companion FOA "CounterACT Optimization of Therapeutic Lead Compound (U01)" (PAR-16-331). The scope of this FOA encompasses Technical Readiness Level (TRL) 3 - see TRLs. Each project must include annual milestones that create discrete go or no-go decision points in a progressive translational study plan.
Federal Grant Title: Countermeasures Against Chemical Threats (CounterACT): Identification of Therapeutic Lead Compounds (U01)
Federal Agency Name: National Institutes of Health
Grant Categories: Environment Health
Type of Opportunity: Discretionary
Funding Opportunity Number: PAR-16-330
Type of Funding: Cooperative Agreement
CFDA Numbers: 324022, 324023, 324024, 324021, 324003
CFDA Descriptions: Environmental Health; Arthritis, Musculoskeletal and Skin Diseases Research; Extramural Research Programs in the Neurosciences and Neurological Disorders; Vision Research
Current Application Deadline: Sep 11, 2018
Original Application Deadline: Sep 11, 2018
Posted Date: Jun 15, 2016
Creation Date: Jun 15, 2016
Archive Date: Oct 12, 2018
Total Program Funding:
Maximum Federal Grant Award: $300,000
Minimum Federal Grant Award: none
Expected Number of Awards:
Cost Sharing or Matching: No
Applicants Eligible for this Grant
Native American tribal governments (Federally recognized)
Special district governments
Public and State controlled institutions of higher education
Private institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
State governments
County governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Public housing authorities/Indian housing authorities
Small businesses
Independent school districts
Others (see text field entitled "Additional Information on Eligibility" for clarification)
For profit organizations other than small businesses
City or township governments
Additional Information on Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Link to Full Grant Announcement
http://grants.nih.gov/grants/guide/pa-files/PAR-16-330.html
Grant Announcement Contact
NIH OER Webmaster FBOWebmaster@OD.NIH.GOV
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National Institutes of Health 301-496-3405
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