Development and Application of New Technologies to Targeted Genome-wide Resequencing in Well-Phenotyped Populations (R01)

The summary for the Development and Application of New Technologies to Targeted Genome-wide Resequencing in Well-Phenotyped Populations (R01) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.

Development and Application of New Technologies to Targeted Genome-wide Resequencing in Well-Phenotyped Populations (R01): Purpose. The National Heart, Lung, and Blood Institute (NHLBI) and National Human Genome Research Institute (NHGRI) solicit grant applications under this Funding Opportunity Announcement (FOA) to develop and validate a resequencing application for cost-effective, high-throughput sequencing of genome-wide medical targets by assembling current and emerging technologies in the areas of DNA target capture and sequencing. The sequencing targets are primarily all exons of the 20,000 protein coding genes identified as RefSeq genes in Entrez Gene database at the National Center for Biotechnology Information (NCBI), which account for 1-2% of the human genome, but could include other types of functional units such as microRNA and regulatory elements. The purpose of developing this resequencing application is to enable the sequencing of thousands of individual DNA samples in NHLBI s well-phenotyped populations in a cost-effective manner. Applicants must therefore demonstrate the potential to reduce costs towards this goal, while providing data of sufficient quality for distinguishing sequence variants. Applicants must develop full-scale targeted genome resequencing systems and work collaboratively within this program to develop standard procedures for this targeted resequencing technology. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. However, when suitable, principal investigators are expected to form working groups on specific challenges. Funds Available and Anticipated Number of Awards: Contingent upon the availability of funds and the receipt of a sufficient number of meritorious applications, the total amount to be awarded is $ 12 million over 2 years. The anticipated number of awards is 3-4. Eligible Institutions/Organizations. Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); State Government; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Non-domestic (non-U.S.) Entity (Foreign Organization); Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Regional Organization; Eligible agencies of the Federal government. Eligible Project Directors/Principal Investigators (PDs/PIs). Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution/organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. Number of Applications. Applicants may not submit more than one application. Renewals and Resubmissions Renewal (formerly competing continuation ) and resubmission applications will not be accepted under this FOA. At this time, it is not known if this FOA will be reissued. Number of PDs/PIs. More than one PD/PI, or multiple PDs/PIs, may be designated on the application.