Development and Improvement of Inbred ES Cell Lines for Use in Generation of Mouse Mutants

The summary for the Development and Improvement of Inbred ES Cell Lines for Use in Generation of Mouse Mutants grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.

Development and Improvement of Inbred ES Cell Lines for Use in Generation of Mouse Mutants: - The goal of this RFA is to improve the efficiency of germline transmission of C57BL/6 ES lines to an extent that permits the use of C57BL/6 ES cell for high throughput gene targeting and the efficient production of C57BL/6 mice carrying a null mutation. - Up to $1.6 million per year for three years is to be awarded through this RFA. - It is anticipated that 1 to 3 awards will be made. - It is anticipated the awards will be funded in July, 2006 for three years. - Awards will be made using the Cooperative Agreement (U01) mechanism. - Eligible organizations include for-profit or non-profit organizations; public or private institutions, such as universities, colleges, hospitals, and laboratories; units of State and local governments; eligible agencies of the Federal government, domestic or foreign; NIH Intramural laboratories may participate as collaborators. Applicants for this RFA must have a proven track record of producing or developing existing ES lines, preferably from C57BL/6 mice, and have themselves or their collaborators used such lines to create mutant germline competent ES cells by targeted, gene trap or transposon mutagenesis. Experience must support the proposed goals to develop a robust ES cell line(s). Documentation of this track record must be included. - Eligible principal investigators with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with his/her institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. - Applicants may submit more than one application, provided they are scientifically distinct. - Investigators who applied for the RFA, "Completion of a Comprehensive Mouse Knockout Resource" (RFA-HG-05-007.) are encouraged to apply. - See Section IV.1 for application materials. - Telecommunications for the hearing impaired is available at: TTY 301-451-0088.