Development of Advanced Genomic Characterization Technologies (SBIR [R43/R44])
The summary for the Development of Advanced Genomic Characterization Technologies (SBIR [R43/R44]) grant is detailed below.
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Development of Advanced Genomic Characterization Technologies (SBIR [R43/R44]): -The National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI) solicit applications for research projects to develop highly innovative and novel genomic analysis technologies to provide new insights and understanding into the role of genetic alterations in cancer. This Funding Opportunity Announcement (FOA) is a component of The Cancer Genome Atlas (TCGA, http://cancergenome.nih.gov) Pilot Project recently announced by the NCI and the NHGRI. The overall aim of The Cancer Genome Atlas initiative is to accelerate the understanding of the molecular basis of cancer through the development and application of high resolution, high throughput genome analysis technologies in the study of human cancer. In addition, the TCGA Pilot Project is designed to assess the technical feasibility and clinical relevance of conducting a comprehensive analysis of genomic alterations found in human cancers. -In this FOA, the term technology denotes methods and tools that enable research including, but not limited to, instrumentation, techniques, and devices for use in basic and translational cancer research. Genomic analysis technologies are distinct from databases, individual reagents and collections of reagents, therapeutic agents, and tissue repositories, which are supported through other initiatives. -The purpose of this FOA is to develop new and improved high resolution, high-throughput technologies to detect alterations in the cancer genome, epigenome, or transcriptome, including, but not limited to: DNA segment copy number, translocations, loss of heterozygosity and epigenomic modifications, and gene expression profiling. Included are significant improvements in sensitivity such that reliable, whole-genome data are generated from 1,000 or fewer cells and from samples that are f flash frozen, embedded and frozen in a cryopreservation medium, such as optimal cutting temperature (OCT) compound. The proposed projects should maximize genome coverage and resolution to provide a complete and comprehensive analysis of the cancer genome, epigenome, and/or transcriptome.
Federal Grant Title: | Development of Advanced Genomic Characterization Technologies (SBIR [R43/R44]) |
Federal Agency Name: | National Institutes of Health |
Grant Categories: | Education Health |
Type of Opportunity: | Discretionary |
Funding Opportunity Number: | RFA-CA-07-029 |
Type of Funding: | Grant |
CFDA Numbers: | 93.39293.393 |
CFDA Descriptions: | Cancer Construction 93.393 Cancer Cause and Prevention Research |
Current Application Deadline: | No deadline provided |
Original Application Deadline: | Aug 25, 2006 |
Posted Date: | Jun 14, 2006 |
Creation Date: | Jun 14, 2006 |
Archive Date: | Sep 24, 2006 |
Total Program Funding: | $2,000,000 |
Maximum Federal Grant Award: | $850,000 |
Minimum Federal Grant Award: | |
Expected Number of Awards: | 10 |
Cost Sharing or Matching: | 93.394 -- Cancer Detection and Diagnosis Research |
- Applicants Eligible for this Grant
- Others (see text field entitled "Additional Information on Eligibility" for clarification) Small businesses
- Additional Information on Eligibility
- Foreign institutions are not eligible to apply. Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with their organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. Under the SBIR program, for both Phase I and Phase II, the primary employment of the PD/PI must be with the small business concern at the time of award and during the conduct of the proposed project. Primary employment means that more than one half of the PD/PI s time is spent in the employ of the small business concern. Primary employment with a small business concern precludes full-time employment at another organization. Occasionally, deviations from this requirement may occur. Such deviations must be approved in writing by the grants management officer after consultation with the NIH SBIR/STTR Program Coordinator. As defined in 42 CFR 52, the PD/PI is the single individual designated by the grantee in the grant application who is responsible for the scientific and technical direction of the project. When the proposed PD/PI clearly does not have sufficient qualifications to assume this role, the application is not likely to receive a favorable evaluation. See announcement for additional information
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