Identification of Biomarkers for Early Detection of Environmentally-Induced Mitochondrial Dysfunction (R01)
The summary for the Identification of Biomarkers for Early Detection of Environmentally-Induced Mitochondrial Dysfunction (R01) grant is detailed below.
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Identification of Biomarkers for Early Detection of Environmentally-Induced Mitochondrial Dysfunction (R01): This funding opportunity announcement (FOA) encourages grant applications from institutions/organizations to develop biomarkers of mitochondrial dysfunction using animal models and other experimental models that can help to identify environmental stressors that inhibit normal mitochondrial function, improve our mechanistic understanding of the effects of mitochondrial toxicants, and develop approaches and candidate markers that will serve as the basis for developing biomarkers of early mitochondrial dysfunction in human population studies linking exposure to disease. Mitochondrial biology is complex, with different responses to stressors, diet composition, and genetic factors observed in different tissues and at different stages of development. Before early biomarkers of mitochondrial dysfunction can be fully developed for human studies, a number of important issues need to be addressed, including enhancing the understanding of how the more severe effects on mitochondrial function in target tissues relate to milder effects in surrogate tissues, understanding whether alterations in mitochondrial endpoints are adaptive or adverse (transient or persistent) effects, and determining which endpoints signal early effects on mitochondrial function before more severe tissue phenotypes are apparent. Many of these questions can be addressed through development of relevant animal and other experimental models to identify robust markers of mitochondrial dysfunction associated with genetic and environmental factors.
Federal Grant Title: | Identification of Biomarkers for Early Detection of Environmentally-Induced Mitochondrial Dysfunction (R01) |
Federal Agency Name: | National Institutes of Health |
Grant Categories: | Environment Health |
Type of Opportunity: | Discretionary |
Funding Opportunity Number: | RFA-ES-11-007 |
Type of Funding: | Grant |
CFDA Numbers: | 93.113 |
CFDA Descriptions: | Environmental Health |
Current Application Deadline: | Feb 03, 2011 |
Original Application Deadline: | Feb 03, 2011 |
Posted Date: | Nov 30, 2010 |
Creation Date: | Nov 30, 2010 |
Archive Date: | Mar 06, 2011 |
Total Program Funding: | $2,500,000 |
Maximum Federal Grant Award: | |
Minimum Federal Grant Award: | |
Expected Number of Awards: | |
Cost Sharing or Matching: | No |
- Applicants Eligible for this Grant
- State governments - County governments - City or township governments - Special district governments - Independent school districts - Public and State controlled institutions of higher education - Native American tribal governments (Federally recognized) - Public housing authorities/Indian housing authorities - Native American tribal organizations (other than Federally recognized tribal governments) - Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education - Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education - Private institutions of higher education - For profit organizations other than small businesses - Small businesses - Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Additional Information on Eligibility
- Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
- Link to Full Grant Announcement
- Information not provided
- Grant Announcement Contact
- NIH OER [email protected]
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