Identifying Autism Susceptibility Genes
The summary for the Identifying Autism Susceptibility Genes grant is detailed below.
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Identifying Autism Susceptibility Genes: The goal of this Request for Applications (RFA) is to solicit applications to identify specific genes and gene variants in localized chromosomal regions that confer susceptibility to autism. Fine mapping of disease loci, or quantitative trait loci (QTLs), is expected to occur in very large datasets of pre-existing samples that have high statistical power for fine mapping autism susceptibility loci. In order to improve the probability of obtaining biologically and clinically meaningful associations between genotypes and disease outcomes, this initiative will not be limited to fine-scale mapping of a disease locus but will proceed to the next level of positional identification of strong candidate genes via assessment of the functional significance of the autism - associated genetic variants. Such assessments should include approaches based on computational biology, comparative and evolutionary genomics, as well as experimental evidence from relevant in v! itro or animal model studies designed to probe the effect of genetic variants on gene expression, splicing or function.Applications are encouraged to focus on complex modes of inheritance that include multiple risk factors, e.g., environmental, multigenic and epigenetic effects. New data collection activities will not be supported. Data - and biomaterials, if possible - analyzed in projects supported under this RFA can be included in a data management and cell repository facility maintained under the NIMH Human Genetics Initiative (http://nimhgenetics.org) and broadly distributed to the scientific community.
| Federal Grant Title: | Identifying Autism Susceptibility Genes |
| Federal Agency Name: | National Institutes of Health |
| Grant Categories: | Income Security and Social Services Health Environment |
| Type of Opportunity: | Discretionary |
| Funding Opportunity Number: | RFA-MH-05-007 |
| Type of Funding: | Grant |
| CFDA Numbers: | 93.11393.173 |
| CFDA Descriptions: | Biological Response to Environmental Health Hazards 93.173 Research Related to Deafness and Communication Disorders |
| Current Application Deadline: | No deadline provided |
| Original Application Deadline: | Apr 19, 2005 |
| Posted Date: | Dec 20, 2004 |
| Creation Date: | Dec 20, 2004 |
| Archive Date: | May 19, 2005 |
| Total Program Funding: | $4,295,000 |
| Maximum Federal Grant Award: | |
| Minimum Federal Grant Award: | |
| Expected Number of Awards: | 2 |
| Cost Sharing or Matching: | 93.242 -- Mental Health Research Grants |
- Applicants Eligible for this Grant
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Small businesses Public and State controlled institutions of higher education Private institutions of higher education State governments County governments City or township governments Special district governments Independent school districts Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Additional Information on Eligibility
- Eligible agencies of the Federal Government are eligible to apply. Foreign institutions are eligible to apply. There is no limit to the number of applications an applicant may submit under the announcement. Applications submitted by Irish-based research teams may include research associates in Northern Ireland.
- Link to Full Grant Announcement
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