Immunoregulation of Gastrointestinal Carcinogenesis (R01)

The summary for the Immunoregulation of Gastrointestinal Carcinogenesis (R01) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.

Immunoregulation of Gastrointestinal Carcinogenesis (R01): -This Funding Opportunity Announcement (FOA) research project (R01) grant applications from researchers interested in the investigations of two aspects of gastrointestinal carcinogenesis: (i) the roles of the mucosal immune system in initiating and maintaining inflammatory responses that contribute to the development of pre-malignant and malignant gastrointestinal cancers; and/or (ii) the molecular mechanism(s) by which immunoregulatory cells dampen inflammation and decrease tumorigenesis. Applications submitted in response to this FOA should be focused on research that will increase our understanding of how the unique gastrointestinal microenvironment shapes mucosal immune responses in the setting of inflammatory disease-associated carcinogenesis. The ultimate goal of this scientific initiative is to generate a comprehensive understanding of how the innate and adaptive immune responses participate in gastrointestinal carcinogenesis. -Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. -This funding opportunity will utilize the NIH investigator-initiated research project (R01) grant mechanism and runs in parallel with a FOA of identical scientific scope (PA-06-290) that utilize the exploratory/developmental (R21) award mechanism. -Eligible organizations include: for-profit organizations; non-profit organizations; public or private institutions, such as universities, colleges, hospitals and laboratories; units of State governments; units of State Tribal governments; units of local governments; units of local Tribal governments; eligible institutions of the Federal government; Domestic institutions; Foreign institutions; and faith-based or community-based organizations. -Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with his/her institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs -Applicants may submit more than one application, provided they are scientifically distinct.