Large Scale Production of Perturbagen-Induced Cellular Signatures (U54)

The summary for the Large Scale Production of Perturbagen-Induced Cellular Signatures (U54) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.
Large Scale Production of Perturbagen-Induced Cellular Signatures (U54): Purpose. This FOA seeks to establish a pilot-scale data production effort to systematize approaches for identifying mechanism-based associations among the effects of disparate biological perturbations, a knowledge base that can be used to study functional relationships among the responding cellular components. The Library of Integrated Network-Based Cellular Signatures (LINCS) program will support the high-throughput collection and integrative computational analysis of informative molecular activity and cellular feature signatures generated in response to a variety of perturbing agents, including siRNAs and small bioactive molecules, which are applied to a set of carefully selected cell types. The resulting knowledge will form the basis of a long-lived resource that can be used broadly by the community. For example LINCS may inform association of disease states with detailed molecular or cellular phenotypes, and ultimately associate disease with specific gene networks, or inform the mechanism of action of known drugs. This FOA seeks to fund pilot-scale data production efforts that will produce a usable initial resource while addressing the following issues: optimization of methods, integration of data, and scalability. Pilot production efforts will interact with multiple future additional components (data analysis and informatics tools; and development and integration of new production-ready technologies) of the LINCS program. Mechanism of Support. This FOA will utilize the U54 specialized centers cooperative agreement award mechanism. It is intended to complement FOAs that will be issued in FY 2011 for development and integration of new production-ready technologies and for development of informatics and data analysis tools for LINCS. Funds Available and Anticipated Number of Awards. We expect to fund up to two awards in FY 2010. Three years of funding may be requested. Total funds available for the program are $2.7M in FY 2010, ramping to $5M in each of FY 2011 and FY 2012.
Federal Grant Title: Large Scale Production of Perturbagen-Induced Cellular Signatures (U54)
Federal Agency Name: National Institutes of Health
Grant Categories: Health
Type of Opportunity: Discretionary
Funding Opportunity Number: RFA-RM-10-003
Type of Funding: Cooperative Agreement
CFDA Numbers: 93.310
CFDA Descriptions: Trans-NIH Research Support
Current Application Deadline: Apr 27, 2010
Original Application Deadline: Apr 27, 2010
Posted Date: Feb 26, 2010
Creation Date: Feb 26, 2010
Archive Date: May 28, 2010
Total Program Funding: $12,700,000
Maximum Federal Grant Award: $900,000
Minimum Federal Grant Award:
Expected Number of Awards:
Cost Sharing or Matching: No
Applicants Eligible for this Grant
State governments - County governments - City or township governments - Special district governments - Independent school districts - Public and State controlled institutions of higher education - Native American tribal governments (Federally recognized) - Public housing authorities/Indian housing authorities - Native American tribal organizations (other than Federally recognized tribal governments) - Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education - Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education - Private institutions of higher education - For profit organizations other than small businesses - Small businesses - Others (see text field entitled "Additional Information on Eligibility" for clarification)
Additional Information on Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Link to Full Grant Announcement
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