Lung Cancer and Inflammation (R01)

The summary for the Lung Cancer and Inflammation (R01) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.

Lung Cancer and Inflammation (R01): -Purpose:This Funding Opportunity Announcement (FOA), issued by the National Cancer Institute (NCI), invites research project grant applications for studies elucidating the role of the microenvironment and inflammation in lung carcinogenesis, as well as studies on the influence of these factors on the cell of origin and putative lung tumor cells. The main objective of this FOA is to stimulate research on lung cancer with a specific emphasis on the mechanisms precipitated by inflammatory changes in the lung microenvironment that are related to carcinogenesis. These investigations are expected to provide new insights into the early cell biological and molecular changes that may occur in lung cells, especially in putative lung stem cells, as they progress from a normal phenotype to a malignant one under the inflammatory influence. -Applications submitted in response to this FOA should emphasize mechanistic studies of inflammation in lung carcinogenesis and how these mechanisms may promote a selective advantage for developing lung tumor cells. The scope of research supported by this FOA could include animal models and cell culture models investigating potential mechanisms involved in the pathogenesis of lung cancer, as well as studies incorporating the analysis of human tissue to define the critical factors leading to lung carcinogenesis. -Applicants are encouraged to interact with and take advantage of the resources available through NCI supported research infrastructures such as the Mouse Models of Human Cancer Consortium, the Early Detection Research Network, and the Specialized Programs in Research Excellence.