Annual Estimates of Influenza Vaccine Effectiveness for Preventing Laboratory-Confirmed Influenza in the United States

The summary for the Annual Estimates of Influenza Vaccine Effectiveness for Preventing Laboratory-Confirmed Influenza in the United States Federal Grant is detailed below. It contains information such as the Catalog of Federal Domestic Assistance (CFDA) number, who is eligible for the grant, how much grant money will be awarded, important deadlines, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed in the Grant Announcement Contact section. If these sections are incomplete, please visit the website of the government agency that is offering this grant.


	Federal Grant Title:	Annual Estimates of Influenza Vaccine Effectiveness for Preventing Laboratory-Confirmed Influenza in the United States
	CFDA Number:	93.185
	CFDA Description:	Immunization Research, Demonstration, Public Information and Education_Training and Clinical Skills Improvement Projects
	Federal Agency Name:	Centers for Disease Control and Prevention
	Category of Funding Activity:	Health
	Category Explanation:	Information not provided
	Opportunity Category:	Discretionary
	Funding Opportunity Number:	RFA-IP-11-003
	Document Type:	Grants Notice
	Funding Instrument Type:	Cooperative Agreement
	Posted Date:	Jan 10, 2011
	Creation Date:	Jan 10, 2011
	Original Closing Date for Applications:	Mar 01, 2011 On-time submission requires that electronic applications be error-free and made available to CDC for processing from eRA Commons on or before the deadline date. Applications must be submitted to and validated successfully by Grants.gov/eRA Commons no later than 5:00 PM Eastern Time. Note:.HHS/CDC grant submission procedures do not provide a period of time beyond the application due date to correct any error or warning notices of noncompliance with application instructions that are identified by Grants.gov or eRA systems (i.e., error correction window).
	Current Closing Date for Applications:	Mar 01, 2011 On-time submission requires that electronic applications be error-free and made available to CDC for processing from eRA Commons on or before the deadline date. Applications must be submitted to and validated successfully by Grants.gov/eRA Commons no later than 5:00 PM Eastern Time. Note:.HHS/CDC grant submission procedures do not provide a period of time beyond the application due date to correct any error or warning notices of noncompliance with application instructions that are identified by Grants.gov or eRA systems (i.e., error correction window).
	Archive Date:	Mar 31, 2011
	Expected Number of Awards:	5
	Estimated Total Program Funding:	Information not provided
	Federal Grant Award Ceiling:	$785,000
	Federal Grant Award Floor:	$0
	Cost Sharing or Matching Requirement:	No

Applicants Eligible for this Grant: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"
Additional Information on Eligibility: Information not provided
Grant Description: Influenza is an important cause of morbidity, mortality, and healthcare burden across all age groups. Because influenza viruses are constantly changing and vaccines are reformulated every year, annual estimates of the effectiveness of influenza vaccines in preventing influenza infection and its associated complications are needed in order to evaluate the protection provided by annual, nationwide vaccination programs. Estimating influenza vaccine effectiveness (VE) as soon as possible after the start of a seasonal influenza epidemic or pandemic and monitoring it over time will be essential in order to guide influenza vaccination and control policy. The populations to be studied will include those for whom CDC's Advisory Committee on Immunization Practices recommends receipt of a licensed influenza vaccine. Influenza vaccination can prevent or reduce a number of outcomes, including laboratory-confirmed influenza virus infection, symptomatic illness given infection, severe illness and related complications due to influenza, the likelihood of transmitting the virus to others, or a combination of these. Thus, accurate estimation of vaccine effectiveness requires a multi-component approach, including accurate assessment of vaccination status, laboratory-confirmed disease outcomes, timing of illness and vaccination, and assessment of other factors that may affect vaccine use and immune response to vaccination. In addition, serological assessment of vaccine response and influenza antibody outcomes among vaccinated and unvaccinated individuals is also needed in order to understand vaccine response. Many additional factors can also affect the assessment of VE in observational studies such as the sensitivity and specificity of outcome measures, specimen collection methods, timing of vaccination, the setting for case and control recruitment, and the ratio of influenza illness to non-influenza respiratory illness. Moreover, a number of potential modifiers of vaccine response and vaccine effectiveness have been identified, including individual factors, environmental factors, and viral and infectious disease factors. Thus, applicants must describe plans to identify and control for a variety of potential confounders in each proposed analysis.
Link to Full Grant Announcement: Information not provided
Grant Announcement Contact: Centers for Disease Control and Prevention (CDC) Procurement and Grants Office (PGO) Technical Information and Managment Section (TIMS) Phone 770-488-2700

General Email [pgotim@cdc.gov]
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