Pilot and Feasibility Program in Human Islet Biology
The summary for the Pilot and Feasibility Program in Human Islet Biology grant is detailed below.
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Pilot and Feasibility Program in Human Islet Biology: Much of our understanding of the basic biology and function of the beta cell and the pancreatic islet comes from studies of immortalized cell lines and mouse tissue. However, differences in the general structure and organization of mouse and human islets have been identified, and it remains uncertain if these structural differences reflect functional differences as well. With the variable success in islet transplantation and the inability to use in vitro data to reliably predict islet engraftment and function, it is important to learn all that we can about the structure, organization, and signaling properties of human islets, and to compare and contrast these findings with those reported with rodent models of islet function used to date. The information gained from these studies should increase our ability to develop new reagents for use in in vivo imaging studies of the human islet, to develop fingerprinting assays for use in predicting human islet transplant success, and to further develop cellular therapies for potential use in the treatment of type 1 diabetes.
Federal Grant Title: | Pilot and Feasibility Program in Human Islet Biology |
Federal Agency Name: | National Institutes of Health |
Grant Categories: | Health |
Type of Opportunity: | Discretionary |
Funding Opportunity Number: | RFA-DK-03-021 |
Type of Funding: | Grant |
CFDA Numbers: | 93.847 |
CFDA Descriptions: | Diabetes, Endocrinology and Metabolism Research |
Current Application Deadline: | No deadline provided |
Original Application Deadline: | November 20, 2003 and July 20, 2004 |
Posted Date: | Jul 22, 2003 |
Creation Date: | Aug 19, 2004 |
Archive Date: | Aug 19, 2004 |
Total Program Funding: | |
Maximum Federal Grant Award: | |
Minimum Federal Grant Award: | |
Expected Number of Awards: | |
Cost Sharing or Matching: | No |
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