Genomic Research in AAT-Deficiency and Sarcoidosis study (GRADS) Cooperative Research Project Grant: Genomics and Informatics Center (GIC) (U01)
The summary for the Genomic Research in AAT-Deficiency and Sarcoidosis study (GRADS) Cooperative Research Project Grant: Genomics and Informatics Center (GIC) (U01) Federal Grant is detailed below.
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Federal Grant Title:
GENOMIC RESEARCH IN AAT-DEFICIENCY AND SARCOIDOSIS STUDY (GRADS) COOPERATIVE RESEARCH PROJECT GRANT: GENOMICS AND INFORMATICS CENTER (GIC) (U01)
State governments - County governments - City or township governments - Special district governments - Independent school districts - Public and State controlled institutions of higher education - Native American tribal governments (Federally recognized) - Public housing authorities/Indian housing authorities - Native American tribal organizations (other than Federally recognized tribal governments) - Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education - Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education - Private institutions of higher education - For profit organizations other than small businesses - Small businesses - Others (see text field entitled "Additional Information on Eligibility" for clarification)
Additional Information on Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
The purpose of this funding opportunity announcement (FOA), issued by NHLBI, NIH, is to invite applications to participate in the NHLBI Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) program, which will assemble a multidisciplinary team of investigators to conduct state-of-art genomic, microbiomics and phenotypic studies of two serious and understudied conditions that affect the lungs: Alpha-1 Antitrypsin Deficiency (AAT) and sarcoidosis. GRADS will include multiple Clinical Centers and one Genomics and Informatics Center (GIC). This FOA solicits applications for the GIC and runs in parallel with a separate FOA that solicits applications for the Clinical Centers (see RFA-HL-12-013). The four main functions of the GRADS GIC are: (1) coordinate activities for the Clinical Centers that will recruit, clinically and immuno- phenotype AAT and sarcoidosis subjects and obtain biospecimens from them, (2) perform transcriptome and microbiome analyses (mRNA, miRNA, viro-, phylo-chip) of the samples obtained by the Clinical Centers, (3) analyze -omic data, testing for associations with the clinical and immune- phenotypes, and (4) prepare a dataset for deposit in the NHLBI BioLINCC repository (https://biolincc.nhlbi.nih.gov/new_data_set_policy/) for distribution to external investigators. This program will require multidisciplinary research collaboration among genomic and microbiome scientists, bioinformaticians, and clinicians with expertise in these diseases.