Genomic Research in AAT-Deficiency and Sarcoidosis study (GRADS) Cooperative Research Project Grant: Genomics and Informatics Center (GIC) (U01)

Applicants Eligible for this Grant

State governments - County governments - City or township governments - Special district governments - Independent school districts - Public and State controlled institutions of higher education - Native American tribal governments (Federally recognized) - Public housing authorities/Indian housing authorities - Native American tribal organizations (other than Federally recognized tribal governments) - Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education - Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education - Private institutions of higher education - For profit organizations other than small businesses - Small businesses - Others (see text field entitled "Additional Information on Eligibility" for clarification)

Additional Information on Eligibility

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grant Description

The purpose of this funding opportunity announcement (FOA), issued by NHLBI, NIH, is to invite applications to participate in the NHLBI Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) program, which will assemble a multidisciplinary team of investigators to conduct state-of-art genomic, microbiomics and phenotypic studies of two serious and understudied conditions that affect the lungs: Alpha-1 Antitrypsin Deficiency (AAT) and sarcoidosis. GRADS will include multiple Clinical Centers and one Genomics and Informatics Center (GIC). This FOA solicits applications for the GIC and runs in parallel with a separate FOA that solicits applications for the Clinical Centers (see RFA-HL-12-013). The four main functions of the GRADS GIC are: (1) coordinate activities for the Clinical Centers that will recruit, clinically and immuno- phenotype AAT and sarcoidosis subjects and obtain biospecimens from them, (2) perform transcriptome and microbiome analyses (mRNA, miRNA, viro-, phylo-chip) of the samples obtained by the Clinical Centers, (3) analyze -omic data, testing for associations with the clinical and immune- phenotypes, and (4) prepare a dataset for deposit in the NHLBI BioLINCC repository (https://biolincc.nhlbi.nih.gov/new_data_set_policy/) for distribution to external investigators. This program will require multidisciplinary research collaboration among genomic and microbiome scientists, bioinformaticians, and clinicians with expertise in these diseases.

Link to Full Grant Announcement

http://grants.nih.gov/grants/guide/rfa-files/rfa-hl-12-014.html

Grant Announcement Contact

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