The Relationship Between Hypertension and Inflammation

The summary for the The Relationship Between Hypertension and Inflammation Federal Grant is detailed below. It contains information such as the Catalog of Federal Domestic Assistance (CFDA) number, who is eligible for the grant, how much grant money will be awarded, important deadlines, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed in the Grant Announcement Contact section. If these sections are incomplete, please visit the website of the government agency that is offering this grant.

	Federal Grant Title:	The Relationship Between Hypertension and Inflammation
	CFDA Number:	93.837
	CFDA Description:	Heart and Vascular Diseases Research
	Federal Agency Name:	National Institutes of Health
	Category of Funding Activity:	Health
	Category Explanation:	Information not provided
	Opportunity Category:	Discretionary
	Funding Opportunity Number:	PA-06-035
	Document Type:	Modification to Previous Grants Notice
	Funding Instrument Type:	Grant
	Posted Date:	Oct 21, 2005
	Creation Date:	Dec 12, 2006
	Original Closing Date for Applications:	Multiple dates, see announcement.
	Current Closing Date for Applications:	Information not provided
	Archive Date:	Feb 03, 2007
	Expected Number of Awards:	Information not provided
	Estimated Total Program Funding:	Information not provided
	Federal Grant Award Ceiling:	Information not provided
	Federal Grant Award Floor:	Information not provided
	Cost Sharing or Matching Requirement:	No

Applicants Eligible for this Grant

Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Special district governments County governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities State governments Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Others (see text field entitled "Additional Information on Eligibility" for clarification)

Additional Information on Eligibility

Eligible agencies of the Federal government Foreign Institutions

Grant Description

This initiative will encourage the study of the sequence of events in which the vascular inflammatory state contributes to the development and maintenance of hypertension. Ample evidence suggests that inflammation may play a role in the pathogenesis of hypertension or that it may characterize a functional state of the vessel wall as a consequence of high blood pressure. Angiotensin II (Ang II), a widely recognized vasoconstrictor and anti-natriuretic involved in blood pressure regulation, also acts as a pro-inflammatory factor in the cardiovascular system. Ang II stimulates the expression of several inflammatory cytokines, which in turn affect blood pressure. A potential linkage between Ang II and immuno-cytokines is their shared ability to induce the level of reactive oxygen species (ROS), which serve as second messengers for many intracellular signaling pathways. The production of ROS not only decreases bioavailability of nitric oxide (NO), a vasodilator, but also initiates the functional and morphological alterations, such as remodeling, in the vascular wall that accompany the hypertensive state over time. This initiative would provide an opportunity to bring focus on the potential causal relationship between hypertension and inflammation in a cohesive, integrated manner. A new understanding of hypertension and inflammation would provide novel opportunities to prevent and treat the disease.

Link to Full Grant Announcement

http://grants.nih.gov/grants/guide/pa-files/PA-06-035.html http://grants.nih.gov/grants/guide/pa-files/PA-06-035.html

Grant Announcement Contact

Webmaster, NIH, Webmaster, Phone not available, Fax not available, Email FBOWebmaster@mail.nih.gov FBOWebmaster@mail.nih.gov Webmaster, NIH

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