Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (R03)

The summary for the Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (R03) Federal Grant is detailed below. It contains information such as the Catalog of Federal Domestic Assistance (CFDA) number, who is eligible for the grant, how much grant money will be awarded, important deadlines, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed in the Grant Announcement Contact section. If these sections are incomplete, please visit the website of the government agency that is offering this grant.


	Federal Grant Title:	Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (R03)
	CFDA Number:	93.310
	CFDA Description:	Trans-NIH Research Support
	Federal Agency Name:	National Institutes of Health
	Category of Funding Activity:	Health
	Category Explanation:	Information not provided
	Opportunity Category:	Discretionary
	Funding Opportunity Number:	PAR-06-545
	Document Type:	Grants Notice
	Funding Instrument Type:	Grant
	Posted Date:	Sep 07, 2006
	Creation Date:	Sep 07, 2006
	Original Closing Date for Applications:	Oct 27, 2007
	Current Closing Date for Applications:	Information not provided
	Archive Date:	Nov 26, 2007
	Expected Number of Awards:	Information not provided
	Estimated Total Program Funding:	$3,700,000
	Federal Grant Award Ceiling:	Information not provided
	Federal Grant Award Floor:	Information not provided
	Cost Sharing or Matching Requirement:	No

Applicants Eligible for this Grant: Others (see text field entitled "Additional Information on Eligibility" for clarification) Public and State controlled institutions of higher education Small businesses Special district governments Public housing authorities/Indian housing authorities City or township governments Independent school districts County governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Additional Information on Eligibility: Foreign institutions are not eligible to apply. Eligible agencies of the Federal Government can apply. Faith-based or community-based organizations can apply. Applicants may submit more than one application, provided each application is scientifically distinct. One application can contain parallel screens for multiple related molecular targets or cellular systems within a screening plan.
Grant Description: -Purpose. This FOA promotes discovery and development of new chemical probes as research tools for use by scientists in both the public and private sector to advance the understanding of biological functions and disease mechanisms. This initiative is one of the integrated components of the NIH Molecular Libraries Roadmap initiative that offers biomedical researchers access to large-scale automated high throughput screening (HTS) centers in the Molecular Libraries Screening Centers Network (MLSCN), diverse compound libraries in the Small Molecule Repository (MLSMR) and information on biological activities of small molecules in the PubChem BioAssay public database. The purpose of this FOA is to solicit HTS assays from the scientific community by identifying investigators who have the interest and capability to work with the molecular libraries screening centers in support of chemical probe development. -Mechanism of Support. This FOA uses the NIH Small Research Grant (R03) award mechanism and runs in parallel with PAR-06-259 that solicits applications for MLSCN under the Resource Access (X01) award mechanism. -Although the R03 mechanism typically does not require preliminary data, for this FOA preliminary data are required for reviewer evaluation of the primary assay. The application must provide a description of a well-developed assay that can be automated for HTS and a systematic plan, including secondary and counter-screening assays, for evaluating active compounds identified in the primary HTS. The application should also include a strategy for further testing, in collaboration with the MLSCN center, to provide a final refinement in structure and function of the active compounds and leading to the optimum chemical probe.
Link to Full Grant Announcement: http://grants.nih.gov/grants/guide/pa-files/PAR-06-545.html http://grants.nih.gov/grants/guide/pa-files/PAR-06-545.html
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