Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (R03)
The summary for the Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (R03) Federal Grant is detailed below.
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Federal Grant Title:
SOLICITATION OF ASSAYS FOR HIGH THROUGHPUT SCREENING (HTS) IN THE MOLECULAR LIBRARIES SCREENING CENTERS NETWORK (R03)
Others (see text field entitled "Additional Information on Eligibility" for clarification) Public and State controlled institutions of higher education Small businesses Special district governments Public housing authorities/Indian housing authorities City or township governments Independent school districts County governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Additional Information on Eligibility
Foreign institutions are not eligible to apply. Eligible agencies of the Federal Government can apply. Faith-based or community-based organizations can apply. Applicants may submit more than one application, provided each application is scientifically distinct. One application can contain parallel screens for multiple related molecular targets or cellular systems within a screening plan.
-Purpose. This FOA promotes discovery and development of new chemical probes as research tools for use by scientists in both the public and private sector to advance the understanding of biological functions and disease mechanisms. This initiative is one of the integrated components of the NIH Molecular Libraries Roadmap initiative that offers biomedical researchers access to large-scale automated high throughput screening (HTS) centers in the Molecular Libraries Screening Centers Network (MLSCN), diverse compound libraries in the Small Molecule Repository (MLSMR) and information on biological activities of small molecules in the PubChem BioAssay public database. The purpose of this FOA is to solicit HTS assays from the scientific community by identifying investigators who have the interest and capability to work with the molecular libraries screening centers in support of chemical probe development. -Mechanism of Support. This FOA uses the NIH Small Research Grant (R03) award mechanism and runs in parallel with PAR-06-259 that solicits applications for MLSCN under the Resource Access (X01) award mechanism. -Although the R03 mechanism typically does not require preliminary data, for this FOA preliminary data are required for reviewer evaluation of the primary assay. The application must provide a description of a well-developed assay that can be automated for HTS and a systematic plan, including secondary and counter-screening assays, for evaluating active compounds identified in the primary HTS. The application should also include a strategy for further testing, in collaboration with the MLSCN center, to provide a final refinement in structure and function of the active compounds and leading to the optimum chemical probe.