Strengthening Clinical and Laboratory Services at the National Referral Level to Improve HIV Prevention, Care, and Treatment in the Republic of Zambia under the President's Emergency Plan for AIDS Relief (PEPFAR)

The summary for the Strengthening Clinical and Laboratory Services at the National Referral Level to Improve HIV Prevention, Care, and Treatment in the Republic of Zambia under the President's Emergency Plan for AIDS Relief (PEPFAR) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the Centers for Disease Control and Prevention, which is the U.S. government agency offering this grant.

Strengthening Clinical and Laboratory Services at the National Referral Level to Improve HIV Prevention, Care, and Treatment in the Republic of Zambia under the President's Emergency Plan for AIDS Relief (PEPFAR):



1. CDC Project Description







a. Approach:







Activities


Outcomes




Short Term Outcomes
(1-2 Years)


Intermediate Outcomes
(3-4 Years)


Long Term Outcomes
(5+ Years)




CARE AND TREATMENT OF HIV INFECTED PERSONS




Provide comprehensive clinical management of HIV infected persons including screening and treatment for TB, sexually transmitted infections (STIs) and opportunistic infections (OIs) and antiretroviral therapy (ART) for treating eligible persons

Evaluate HIV disease stage and initiate ART for all HIV infected persons who meet national eligibility criteria

Perform TB syndromic screening of HIV patients, followed by laboratory confirmation and TB treatment, as needed, and provide Isoniazid prophylaxis to TB screen negative patients

Provide cotrimoxazole (CTX) prophylaxis to HIV infected persons, according to national guidelines

Evaluate HIV patients for STIs or OIs and treat as needed

Strengthen linkages for patient referrals within the host facility and to named primary care facilities by providing quarterly lists of referred patients to sites and requesting feedback on referral outcome and retention of patients on ART


Increased number of HIV infected children initiated on ART

Increased number of adults initiated on ART


Increased uptake of ART initiation among HIV infected persons

Increased number of HIV infected persons appropriately managed and treated for TB, STIs and OIs


Improved virological suppression among HIV infected persons receiving appropriate clinical management and treatment

Increased retention of patients on ART




Monitor the impact of ART on individuals through viral load (VL) testing and HIV drug resistance testing for those with suspected treatment failure

Implement viral load (VL) testing for all persons on ART at 6 months and 12 months, and annually thereafter, and use VL test results to adjust treatment regimens, according to national guidelines

Implement HIV drug resistance (DR) testing of patients with suspected ART treatment failure


Increased number of HIV infected persons on ART with VL results available according to schedule

Increased number of persons with suspected treatment failure with available HIV DR test results


Increased number of persons with suspected ART treatment failure on appropriate anti-retroviral (ARV) treatment regimen based on HIV DR results


Increased use of effective ARV treatment regimens that lead to viral suppression




Provide nutritional counseling, as appropriate, to HIV infected persons and their families


Increased number of HIV infected persons receiving nutritional advice and management


Reduced morbidity due to nutritional deficiencies among HIV infected persons and their families


Reduced morbidity due to nutritional deficiencies among HIV infected persons and their families




Assist MOH to strengthen skills of clinicians and develop guidelines to improve care and treatment of HIV/AIDS patients


Increased number of clinicians mentored in other health care facilities by Partner’s staff

Increased number of provinces with newly established Advanced HIV Treatment Centers to manage complicated HIV cases e.g. patients failing second line therapy, needing HIV DR testing to guide selection of ART regimen, or, with complicated co-morbidities (e.g. with advanced cardiac failure and end stage renal failure)


Increased number of HIV infected persons appropriately managed and treated


Improved virological suppression among HIV infected persons receiving appropriate clinical management and treatment

Increased retention of patients on ART





Continued under..2. CDC Project Description