The Relationship Between Hypertension and Inflammation (R01)

The summary for the The Relationship Between Hypertension and Inflammation (R01) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.
The Relationship Between Hypertension and Inflammation (R01): -Purpose. This Funding Opportunity Announcement (FOA) solicits grant applications that propose the study of the sequence of events in which the vascular inflammatory state contributes to the development and maintenance of hypertension. Ample evidence suggests that inflammation may play a role in the pathogenesis of hypertension or that it may characterize a functional state of the vessel wall as a consequence of high blood pressure. Angiotensin II (Ang II), a widely recognized vasoconstrictor and anti-natriuretic involved in blood pressure regulation, also acts as a pro-inflammatory factor in the cardiovascular system. Ang II stimulates the expression of several inflammatory cytokines, which in turn affect blood pressure. A potential linkage between Ang II and immuno-cytokines is their shared ability to induce the level of reactive oxygen species (ROS), which serve as second messengers for many intracellular signaling pathways. The production of ROS not only decreases bioavailability of nitric oxide (NO), a vasodilator, but also initiates the functional and morphological alterations, such as remodeling, in the vascular wall that accompany the hypertensive state over time. This FOA would provide an opportunity to bring focus on the potential causal relationship between hypertension and inflammation in a cohesive, integrated manner. A new understanding of hypertension and inflammation would provide novel opportunities to prevent and treat the disease. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. -Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the numbers, quality, duration, and costs of the applications received.
Federal Grant Title: The Relationship Between Hypertension and Inflammation (R01)
Federal Agency Name: National Institutes of Health
Grant Categories: Health
Type of Opportunity: Discretionary
Funding Opportunity Number: PA-07-138
Type of Funding: Grant
CFDA Numbers: 93.837
CFDA Descriptions: Heart and Vascular Diseases Research
Current Application Deadline: No deadline provided
Original Application Deadline: Multiple Receipt Dates - See Link to Full Announce
Posted Date: Dec 12, 2006
Creation Date: Dec 12, 2006
Archive Date: Dec 05, 2008
Total Program Funding:
Maximum Federal Grant Award:
Minimum Federal Grant Award:
Expected Number of Awards:
Cost Sharing or Matching: No
Applicants Eligible for this Grant
Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled "Additional Information on Eligibility" for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments For profit organizations other than small businesses Independent school districts Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Special district governments City or township governments State governments
Additional Information on Eligibility
Foreign institutions are not eligible to apply. Eligible agencies of the Federal Government can apply. Faith-based or community-based organizations can apply.
Link to Full Grant Announcement
Information not provided
Grant Announcement Contact
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster
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