Mechanisms Mediating Changes in Central Regulation of Bone Mass (R01)
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Mechanisms Mediating Changes in Central Regulation of Bone Mass (R01): Purpose This FOA issued by the National Institute on Aging (NIA), National Institutes of Health (NIH), solicits Research Project Grant (R01) applications from institutions/ organizations that propose to investigate neural, neuroendocrine and/or related integrative physiological mechanisms that mediate age dependent changes in bone metabolism and health. The discovery that leptin, secreted by adipocytes, regulates bone mass through a central relay involving serotonergic neurons has generated considerable interest and raised many additional questions about the identity of neural mediator(s) linking the brain to skeletal physiology as well as the potential involvement of other factors whether they be neural/hypothalamic factors (Serotonin, TSH and FSH, ephrins, dynorphins, endocannabiniods/receptors) or other factors such as ACTH, as well as distant tissues/organs such as adipose tissue) in regulating bone mass as well as distant tissues/organs. In addition, recent reports indicate that direct innervations are important in mechanical load sensing and bone remodeling. Furthermore, in view of the well documented age-related changes in neuroendocrine activity, this emerging field of research will significantly reshape our understanding of mechanisms modulating age-related changes in bone mass (increase or decrease in bone mass and/or the etiology of osteoporosis). We are interested in studies to identify and characterize age-related changes in these factors that serve to integrate activity influencing bone mass as well as integrative cross talk mechanisms (neural, endocrine, immune or novel) that coordinate these signaling pathways. Mechanism of Support. This FOA will utilize the R01 grant mechanism. Funds Available and Anticipated Number of Awards NIA will fund 3-5 applications with annual budgets up to and including $250,000 in direct costs for up to 5 years depending upon receipt of an adequate number of meritorious applications.
Federal Grant Title: | Mechanisms Mediating Changes in Central Regulation of Bone Mass (R01) |
Federal Agency Name: | National Institutes of Health |
Grant Categories: | Health |
Type of Opportunity: | Discretionary |
Funding Opportunity Number: | RFA-AG-11-006 |
Type of Funding: | Grant |
CFDA Numbers: | 93.866 |
CFDA Descriptions: | Aging Research |
Current Application Deadline: | Oct 14, 2010 |
Original Application Deadline: | Oct 14, 2010 |
Posted Date: | Aug 03, 2010 |
Creation Date: | Aug 03, 2010 |
Archive Date: | Nov 14, 2010 |
Total Program Funding: | $1,500,000 |
Maximum Federal Grant Award: | $250,000 |
Minimum Federal Grant Award: | |
Expected Number of Awards: | |
Cost Sharing or Matching: | No |
- Applicants Eligible for this Grant
- State governments - County governments - City or township governments - Special district governments - Independent school districts - Public and State controlled institutions of higher education - Native American tribal governments (Federally recognized) - Public housing authorities/Indian housing authorities - Native American tribal organizations (other than Federally recognized tribal governments) - Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education - Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education - Private institutions of higher education - For profit organizations other than small businesses - Small businesses - Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Additional Information on Eligibility
- Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
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- Information not provided
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- NIH OER [email protected]
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