Molecular Libraries Screening Centers Network (Mlscn)

The summary for the Molecular Libraries Screening Centers Network (Mlscn) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.

Molecular Libraries Screening Centers Network (Mlscn): The Institutes and Centers (ICs) of the NIH invite applications from investigators interested in participating in an NIH Roadmap pilot program to establish the Molecular Libraries Screening Centers Network (MLSCN). The MLSCN will be a national resource capable of providing innovative high throughput molecular screening (HTS) approaches for the identification of small organic molecules (compounds) that are active in biological assays, and synthetic chemistry to improve the utility of these molecules as bioactive probes for in vitro, and potentially in vivo, studies of normal and abnormal physiology of cells, organs, model systems, and/or organisms. The over-arching goal of the MLSCN is to screen large numbers of compounds to identify and subsequently optimize small molecules that selectively interact with specific biological targets so that they may be used as probes to understand the function of newly characterized proteins, and to analyze physiological processes, cellular phenomena, and disease mechanisms. NIHs primary objective for this new public sector screening effort is to identify compounds that will constitute a new set of research tools for use by scientists in both the public and private sector. In addition, it is anticipated that some of these compounds will be used by both public and private sector scientists as chemical platforms that may lead to new therapeutics. Accordingly, NIH intends that all of the data and information generated by the MLSCN will be made publicly available in a new database to be known as PubChem. In this regard, NIH recognizes that there are significant issues concerning intellectual property rights with respect to patentable inventions developed during the MLSCN program. This subject is discussed more fully below. Within this context however, it is NIHs hope that inventors will exercise any intellectual property rights retained on inventions developed as part of the MLSCN program in a way that will promote wide accessibility to and further development of the resources that are generated. Applications are invited from groups that have the interest and capabilities to develop and/or expand their assay development/optimization, screening, and synthetic chemistry operations as well as groups with established capabilities in these domains.