More Monitoring of Cognitive Change, Continued (M3C3) (U2C Clinical Trial Optional)

The summary for the More Monitoring of Cognitive Change, Continued (M3C3) (U2C Clinical Trial Optional) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.

More Monitoring of Cognitive Change, Continued (M3C3) (U2C Clinical Trial Optional): This Funding Opportunity Announcement (FOA) invites applications to expand the content, design, and implementation of research infrastructure funded under FOA RFA-AG-18-012 Mobile Monitoring of Cognitive Change (U2C), also known as the Mobile Toolbox (MTB) Project. The expansion aims to (1) add assessments on mobile devices of non-cognitive socioemotional psychological functions, health states, and contextual factors that may modify cognitive performance; and (2) enable widespread dissemination and support for use of the tools developed for monitoring of age, state, context, or health condition-related changes in cognitive and non-cognitive abilities on mobile devices. The expanded MTB efforts must include the development, or support for development, of applications on the two leading smartphone platforms, the Android and iOS platforms, and the validation of new tests and items to be used on the platforms by age groups ranging from 20 to 85. The goals of this expanded platform are to support data collection efforts from participants enrolled in the project awarded through this FOA, as well as other NIH-funded studies through fiscal year 2027, and to enable the widespread sharing of both the collected data and the test instruments. Thus, research supported through this FOA will continue the development of the MTB platform as described above, with expanded content, wider dissemination, the ability to add study-specific measures, and leverage a shared data processing backend. Additionally, supported research will aim to bring to maturity a model for future cost recovery, via standardized subcontracting terms, conditions, and costs, that will allow the platform to remain continuously updated and available for widespread use as the easiest means for researchers to collect real-time, real-world, temporally extended data most relevant to the early detection and study of Alzheimers disease (AD) and AD-related dementias (ADRD).