Prefrontal Cortical Influences on Brain Systems Supporting Complex Mental Function (R01)

The summary for the Prefrontal Cortical Influences on Brain Systems Supporting Complex Mental Function (R01) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.

Prefrontal Cortical Influences on Brain Systems Supporting Complex Mental Function (R01): -Purpose. This funding opportunity announcement (FOA) solicits R01 grant applications that propose to use novel electrophysiological, molecular, genetic and/or imaging techniques in animals to examine the fundamental mechanisms by which regions in the mature and developing prefrontal cortex interact with other cortical and sub cortical systems to give rise to sophisticated behavior and complex mental function (e.g., cognition, emotion, reward, motivation). This FOA seeks applications employing sophisticated approaches that enable precise spatio-temporal manipulation of circuits to better understand how the prefrontal cortex influences the function of these brain networks and their development. It is expected that applications will use non-human primates where the anatomical and functional homology of the prefrontal cortex with humans has been relatively well established. The use of rodents to develop novel approaches to manipulate prefrontal circuitry and examine associated complex behaviors will be considered if these techniques have the clear potential for near-term translation to non-human primates. -Mechanism of Support. This Funding Opportunity Announcement (FOA) will utilize the R01 grant mechanism and runs in parallel with an FOA of identical scientific scope, RFA-MH-08-111 that solicits applications under the R21 Exploratory/Development grant mechanism. -Funds Available and Anticipated Number of Awards. The NIMH Intends to commit approximately $1,000,000 to fund 3-4 grants submitted in response to this and the related FOA MH-08-111. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.