Quantify the expression of metabolizing enzymes and transporter proteins in lung, eye and skin tissue in relevant animal models and humans

The summary for the Quantify the expression of metabolizing enzymes and transporter proteins in lung, eye and skin tissue in relevant animal models and humans grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the Food and Drug Administration, which is the U.S. government agency offering this grant.

Quantify the expression of metabolizing enzymes and transporter proteins in lung, eye and skin tissue in relevant animal models and humans: The purpose of this funding opportunity is to systematically quantify the protein levels of potential metabolizing enzymes and transporters in rabbit eye and human eye tissue, human skin tissue, or human lung tissue using most advanced techniques available. Subsequently, the experimental data collected from this study will be implemented into existing modeling platforms to allow for virtual BE assessments locally and systemically for the parent and its pharmacologically active metabolite (for example, prodrugs where it may be important to track both the parent and the active metabolite). Upon the successful completion of this research, it is expected that the implemented enhancements will improve the predictive power of PBPK models that will be utilized to inform decisions on generic ophthalmic, dermal, and orally inhaled drug product development and to perform virtual BE assessments in support of regulatory decisions.

Federal Grant Title:	Quantify the expression of metabolizing enzymes and transporter proteins in lung, eye and skin tissue in relevant animal models and humans
Federal Agency Name:	Food and Drug Administration (HHS-FDA)
Grant Categories:	Agriculture Consumer Protection Food and Nutrition
Type of Opportunity:	Discretionary
Funding Opportunity Number:	FOR-FD-20-025
Type of Funding:	Cooperative Agreement
CFDA Numbers:	93.103
CFDA Descriptions:	Information not provided
Current Application Deadline:	February 1st, 2021
Original Application Deadline:	February 1st, 2021
Posted Date:	May 25th, 2021
Creation Date:	May 25th, 2021
Archive Date:	May 26th, 2021
Total Program Funding:
Maximum Federal Grant Award:
Minimum Federal Grant Award:
Expected Number of Awards:
Cost Sharing or Matching:	No
Last Updated:	May 25th, 2021

Applicants Eligible for this Grant: State governments - County governments - City or township governments - Special district governments - Independent school districts - Public and State controlled institutions of higher education - Native American tribal governments (Federally recognized) - Public housing authorities/Indian housing authorities - Native American tribal organizations (other than Federally recognized tribal governments) - Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education - Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education - Private institutions of higher education - For-profit organizations other than small businesses - Small businesses
Grant Announcement Contact: Shashi Malhotra
Grants Management Specialist
[email protected]
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