Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (MLSCN)

The summary for the Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (MLSCN) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.

Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (MLSCN): The Molecular Libraries Screening Centers Network (MLSCN), launched on June 15, 2005, is a new national high-throughput biological screening resource. The goal of the MLSCN is to empower the research community to use small molecule compounds in their research, whether as tools to modulate genes and pathways, as imaging probes in basic or clinical applications, or as starting points for the development of new therapeutics for human disease. The MLSCN will be the engine of discovery in the NIH Roadmap Molecular Libraries initiative. Using compounds from the MLSCN Small Molecule Repository and supported by the informatics capabilities of NIH's PubChem, the MLSCN will provide researchers with many new chemical tools to explore cellular functions at the molecular level. In order to achieve this goal, the ten network screening centers will screen a large collection of compounds in a variety of innovative assays to identify and subsequently optimize small mol! ecules that selectively interact with specific biological targets or pathways. This large collaborative effort will accelerate the pace of the application of chemical biology to the understanding of biology and disease mechanisms. Through this Program Announcement with special review (PAR), the MLSCN is soliciting applications from investigators who have developed innovative assays and are interested in having them used in the MLSCN to screen a large number of compounds maintained in a central Small Molecule Repository, and furthermore, interested in expanding the utility of their assay(s) for producing useful in vitro and/or in vivo chemical probes.