Technologies for Host Resilience (THoR)

The summary for the Technologies for Host Resilience (THoR) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the DARPA Biological Technologies Office, which is the U.S. government agency offering this grant.

Technologies for Host Resilience (THoR): This program strives to discover host tolerance mechanisms in order to identify a suite of interventions suitable for use in humans to mitigate the deleterious effects of infectious diseases. THoR is seeking novel methods and technologies to discover and understand these responses in hosts that are resilient when exposed to infectious diseases. Specifically, DARPA aims to discover the fundamental biological relationships that underlie host tolerance to infection in animal populations in order to provide the foundational knowledge required to develop interventions for potential transition into clinical use. This program is organized into three Technical Areas (TAs): 1) Identification and characterization of animal hosts with tolerant phenotypes; 2) Discovery of biological mechanisms that underlie tolerance; and 3) Identification of interventions that utilize tolerance mechanisms with the goal of reducing morbidity and mortality due to infection. This BAA will focus specifically on understanding tolerance mechanisms in prospective animal studies in conjunction with the analysis of retrospective pre-clinical and human clinical datasets.