Biomolecular Systems Cluster

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Biomolecular Systems Cluster: The Biomolecular Systems Cluster, one of three thematic areas within the Division of Molecular and Cellular Biosciences, supports fundamental research in the areas of molecular biophysics, molecular biochemistry, and metabolic biochemistry. The cluster emphasizes the relationships between structure, function, and dynamics in studies of individual macromolecules, macromolecular complexes, and metabolic pathways. Research of interest to the cluster includes novel and creative projects addressing protein folding and dynamics, natively unfolded proteins, protein design, molecular recognition, enzymology, energy transformations in living systems, and the components, architecture and flux in metabolic pathways. The cluster encourages research projects integrating theoretical, computational, and experimental approaches to discover and define basic molecular mechanisms, as well as projects developing cutting-edge technologies in the context of biological questions relevant to the cluster. The cluster also encourages multi-disciplinary research at the interface of biology with physics, chemistry, mathematics, computer science, and engineering. Program Directors:Kamal Shukla. Molecular biophysics; computational biology, NMR and spectroscopy.Jose Arguello. Molecular biochemistry, membrane proteins, metallo-biochemistry.Robert L. Burnap. Metabolic biochemistry in bacteria and plants, protein structure-function, photosynthesis.Wilfredo Colon. Molecular biophysics; protein folding and stability.Wilson Francisco. Metabolic and molecular biochemistry; enzymology, metalloproteins, protein structure and function.Neocles B. Leontis. Nucleic acid structure, folding & dynamics; protein-nucleic acid interactions.David Rockcliffe. Molecular biochemistry; enzymology.