Clinical Centers for the Severe Asthma Research Program (SARP) (U10)

The summary for the Clinical Centers for the Severe Asthma Research Program (SARP) (U10) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.
Clinical Centers for the Severe Asthma Research Program (SARP) (U10): Purpose. The National Heart, Lung, and Blood Institute invites to participate as a Clinical Center in the NHLBI Severe Asthma Research Program (SARP). Accumulating evidence suggests that severe asthma is complex and phenotypically heterogeneous across individuals and time. Not knowing the underlying mechanisms and stability of these sub-phenotypes impedes the development of effective treatments and management strategies. This phase of SARP will develop a new paradigm for understanding severe asthma and its sub-phenotypes, in children and adults, by defining disease at the molecular and cellular level longitudinally. The new SARP investigators will use mechanistic and evoked phenotype approaches to characterize developmental molecular, cellular and physiologic phenotypes in children and adults with mild to severe asthma and to further elucidate the evolving pathobiology and pathogenesis of severe asthma and its sub-phenotypes. SARP investigators will work together to identify the important research questions that require a shared longitudinal protocol which will be conducted across all participating centers and which will include common information on all SARP participants. In addition, SARP investigators will identify mechanistic research questions separate from those proposed for the shared longitudinal protocol which may be investigated using the shared protocol or in participants from one or more centers. The overall aim is to enable prediction of phenotype stability / fluctuation and pharmacologic response, and to identify novel, disease-modifying targets for treatment. This longitudinal mechanistic research approach will provide integrated understanding of the fixed and variable molecular, cellular, and pathophysiologic underpinnings of severe asthma sub-phenotypes. Cross-sectional studies or therapeutic trials are not the intent of this FOA. This program will require multidisciplinary research collaboration and partnerships between asthma clinician-scientists and scientists with expertise in areas such as immunology, pulmonary physiology, molecular genetics, molecular phenotyping, imaging, and bioinformatics. SARP will consist of up to six Clinical Centers, a Clinical Coordinating Center (CCC), and a Steering Committee. This FOA solicits applications for Clinical Centers and runs parallel with a separate FOA that solicits applications for the Clinical Coordinating Center (see RFA-HL-11-030).
Federal Grant Title: Clinical Centers for the Severe Asthma Research Program (SARP) (U10)
Federal Agency Name: National Institutes of Health
Grant Categories: Health
Type of Opportunity: Discretionary
Funding Opportunity Number: RFA-HL-11-018
Type of Funding: Cooperative Agreement
CFDA Numbers: 93.838
CFDA Descriptions: Lung Diseases Research
Current Application Deadline: Oct 15, 2010
Original Application Deadline: Oct 15, 2010
Posted Date: May 26, 2010
Creation Date: May 26, 2010
Archive Date: Nov 15, 2010
Total Program Funding: $31,500,000
Maximum Federal Grant Award:
Minimum Federal Grant Award:
Expected Number of Awards:
Cost Sharing or Matching: No
Applicants Eligible for this Grant
State governments - County governments - City or township governments - Special district governments - Independent school districts - Public and State controlled institutions of higher education - Native American tribal governments (Federally recognized) - Public housing authorities/Indian housing authorities - Native American tribal organizations (other than Federally recognized tribal governments) - Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education - Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education - Private institutions of higher education - For profit organizations other than small businesses - Small businesses - Others (see text field entitled "Additional Information on Eligibility" for clarification)
Additional Information on Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
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