DOD Amyotrophic Lateral Sclerosis, Clinical Outcomes and Biomarkers Award
The summary for the DOD Amyotrophic Lateral Sclerosis, Clinical Outcomes and Biomarkers Award grant is detailed below.
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DOD Amyotrophic Lateral Sclerosis, Clinical Outcomes and Biomarkers Award: The FY24 ALSRP Clinical Outcomes and Biomarkers Award (COBA) supports the development and/or validation of clinical outcomes and biomarkers to enrich clinical trials in Amyotrophic Lateral Sclerosis (ALS). Projects can be relevant to a specific therapy, a class of therapeutics, or to a specific ALS subtype (such as a particular genetic mutation) and do not have to broadly apply to all patients.Research may include, but is not limited to:Target engagement biomarkers.Objective pharmacodynamic biomarkers to measure the biological effect of an investigational therapeutic.Predictive/cohort-selective biomarkers that indicate whether a specific therapy will be effective in an individual patient or patient subgroup.Diagnostic, prognostic, or disease progressionValidate clinician-, observer-, patient-reported and/or performance outcomes to better support clinical trial success metrics.Define ALS subtypes using patient-based resources to link biosamples and/or digital data elements to rigorous molecular and clinical data.Realize improved strategies that better measure disease progression for people living with ALS.Augment biospecimens, outcome, or digital health data to an on-going clinical trial.Correlate clinical-trial related data (e.g., biosample, imaging, digital health data) with clinical outcomes or responses to therapies.Use of existing well-characterized and highly curated clinical resources is encouraged. Examples of patient-based ALS resources include ongoing or completed clinical trial datasets, biorepositories of clinical specimens, registries (e.g., Centers for Disease Control and Prevention National ALS Registry and/or Biorepository; https://www.cdc.gov/als/Default.html), large omics datasets, patient-report outcomes, digital biomarker datasets, and databases of clinical data and/or metadata. Active-duty military and/or Veteran patient populations or resources should be considered. A list of suitable resources can be found on the ALSRP web page (https://cdmrp.health.mil/alsrp/resources/ALSRPresources). Other resources may be used, provided they have an adequate description of repository parameters and mechanisms for broad access.
Federal Grant Title: | DOD Amyotrophic Lateral Sclerosis, Clinical Outcomes and Biomarkers Award |
Federal Agency Name: | Dept of the Army USAMRAA (DOD-AMRAA) |
Grant Categories: | Science and Technology and other Research and Development |
Type of Opportunity: | Discretionary |
Funding Opportunity Number: | HT942524ALSRPCOBA |
Type of Funding: | Cooperative Agreement |
CFDA Numbers: | 12.420 |
CFDA Descriptions: | Information not provided |
Current Application Deadline: | July 10th, 2024 |
Original Application Deadline: | July 10th, 2024 |
Posted Date: | March 25th, 2024 |
Creation Date: | March 25th, 2024 |
Archive Date: | August 9th, 2024 |
Total Program Funding: | $6,100,000 |
Maximum Federal Grant Award: | |
Minimum Federal Grant Award: | |
Expected Number of Awards: | 5 |
Cost Sharing or Matching: | No |
Last Updated: | March 25th, 2024 |
- Applicants Eligible for this Grant
- Unrestricted (i.e., open to any type of entity below), subject to any clarification in text field entitled "Additional Information on Eligibility"
- Grant Announcement Contact
- CDMRP Help Desk
Phone: 301-682-5507
Email: [email protected]
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